Abstract
Development of single-dose tolerance to diazepam-induced neurologic deficits was assessed in mice by means of a rotarod test. Diazepam suspended in corn oil was administered orally in doses 5–20 mg/kg. Tolerance was found following a second administration of diazepam 24 h after a first dose. It decayed gradually over 4–5 weeks. Hence tolerance persists considerably longer than measurable amounts of diazepam or its metabolites are likely to be present in mice.
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Henauer, S.A., Gallaher, E.J. & Hollister, L.E. Long-lasting single-dose tolerance to neurologic deficits induced by diazepam. Psychopharmacology 82, 161–163 (1984). https://doi.org/10.1007/BF00427765
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DOI: https://doi.org/10.1007/BF00427765