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Psychopharmacology

, Volume 82, Issue 3, pp 161–163 | Cite as

Long-lasting single-dose tolerance to neurologic deficits induced by diazepam

  • Stephan A. Henauer
  • Edward J. Gallaher
  • Leo E. Hollister
Original Investigations

Abstract

Development of single-dose tolerance to diazepam-induced neurologic deficits was assessed in mice by means of a rotarod test. Diazepam suspended in corn oil was administered orally in doses 5–20 mg/kg. Tolerance was found following a second administration of diazepam 24 h after a first dose. It decayed gradually over 4–5 weeks. Hence tolerance persists considerably longer than measurable amounts of diazepam or its metabolites are likely to be present in mice.

Key words

Diazepam Single-dose tolerance Rotarod test Ataxia Neurologic deficits 

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Copyright information

© Springer-Verlag 1984

Authors and Affiliations

  • Stephan A. Henauer
    • 1
  • Edward J. Gallaher
    • 1
  • Leo E. Hollister
    • 1
  1. 1.Veterans Administration Medical CenterPalo AltoUSA

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