Effects of benzazepine (Sch-12679) on shock-induced fighting and locomotor behavior in rats
Benzazepine (Sch-12679) reduced the shock-induced fighting behavior of rats in a dosedependent fashion. However, the drug also impaired both locomotor behavior and rotorod performance. These results suggest that the aggression suppressive effects of Sch-12679 may be mediated by drug-induced sedation.
Key wordsSch-12679 Benzazepine Aggression Shock-induced fighting Locomotor activity
Unable to display preview. Download preview PDF.
- Avis, H.: The neuropharmacology of aggression: a critical review. Psychol. Bull. 81, 47–63 (1974)Google Scholar
- Barnett, A., Taber, R. I., Steiner, S. S.: The behavioral pharmacology of Sch-12679: a new psychoactive agent. Psychopharmacologia (Berl.) 36, 281–290 (1974)Google Scholar
- Itil, T. M., Stock, M. J., Duffy, A. D., Esquenasi, A., Saleuty, B., Han, T. H.: Therapeutic trials and EEG investigations with Sch-12679 in behaviorally disturbed adolescents. Curr. Ther. Res. 14, 136–150 (1972)Google Scholar
- Katz, R. J., Thomas, E.: Effects of a novel anti-aggressive agent upon two types of brain stimulated emotional behavior. Psychopharmacology 48, 79–82 (1976)Google Scholar
- Keskiner, A., Itil, T. M., Han, T. H., Saletu, B., Hsu, W.: Clinical toxicological and electroencephalographic study with Sch-12679 in chronic schizophrenics. Curr. Ther. Res. 13, 714–725 (1971)Google Scholar
- Park, S., Gershon, S., Floyd, A.: A clinical trial of benzazepine (Sch-12679) in acute schizophrenic patients. Curr. Ther. Res. 14, 298–302 (1972)Google Scholar
- Winer, B. J.: Statiscal principles in experimental design. New York: McGraw-Hill 1971Google Scholar