Abstract
Intermittent haloperidol treatment in mice increased 3H-spiroperidol binding to the same degree as continual haloperidol feeding. The results do not support the concept that drug holidays can reduce the incidence of tardive dyskinesia.
References
Burt, D. R., Creese, I., Snyder, S. H.: Properties of 3H-haloperidol and 3H-dopamine binding associated with dopamine receptors in calf brain membranes. Mol. Pharmacol. 12, 800–812 (1976)
Clow, A., Jenner, P., Theodorou, A., Marsden, C. D.: Striatal dopamine receptors become supersensitive while rats are given trifluoperazine for six months. Nature 278, 59–61 (1979)
Ebstein, R. P., Pickholz, D., Belmaker, R. H.: Dopamine receptors changes after long-term haloperidol treatment in rats. J. Pharm. Pharmacol. 51, 558–559 (1979a)
Ebstein, R. P., Pickholz, D., Sternberg, S., Strajelevich, D., Belmaker, R. H.: Chronic high dose propranolol does not increase dopamine receptor number. J. Pharm. Pharmacol. 31, 860–861 (1979b)
Editorial: Tardive dyskinesia. Lancet 1979II, 447–448
Jeste, D. V., Potkin, S. G., Sinha, S., Feder, S., Wyatt, R. J.: Tardive dyskinesia: Reversible and persistent. Arch. Gen. Psychiatry 36, 585–590 (1979)
Klawans, H. L., Hitri, A., Nausieda, P. A., Weiner, W. L.: Animal models of dyskinesia. In: Animal models in psychiatry and neurology, I. Hanin, E. Usdin, eds., pp. 351–363. Oxford: Pergamon 1977
Kobayashi, R. M.: Drug therapy of tardive dyskinesia. New Engl. J. Med. 296, 257–260 (1977)
Tarsy, D., Baldessarini, R. J.: Behavioral supersensitivity to apomorphine following chronic treatment with drugs which interfere with the synaptic function of catecholamines. Neuropharmacology 13, 927–940 (1974)
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Bannet, J., Belmaker, R.H. & Ebstein, R.P. The effect of drug holidays in an animal model of tardive dyskinesia. Psychopharmacology 69, 223–224 (1980). https://doi.org/10.1007/BF00427654
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DOI: https://doi.org/10.1007/BF00427654