Abstract
Experiments are reported which show that 1 mg/kg of d-methylamphetamine HCl induced hyperactivity in pigmented strains (C57BR, C57BL/6, and SEC) and hypoactivity or no change in albino strains (BALB/c, A, and AKR) of mice. In F1 hybrids, the B6 genotype was partially dominant over BR and C, and BR over C. In animals back-crossed to C parents widespread distributions with two peaks were obtained in control experiments, and amphetamine induced hyperactivity in 38% of the albino population, and hypoactivity or no significant change in 45% of the pigmented one. This genetic study indicates that genes influencing locomotor activity are independent from those influencing amphetamine sensitivity. From results obtained in back-crosses and C57BL/6-c2J mice, the albino gene does not seem to be involved in the hypoactive effect of amphetamine.
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Kitahama, K., Valatx, JL. Strain differences in amphetamine sensitivity in mice. Psychopharmacology 66, 189–194 (1979). https://doi.org/10.1007/BF00427629
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DOI: https://doi.org/10.1007/BF00427629