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Psychopharmacology

, Volume 66, Issue 2, pp 147–153 | Cite as

Effets du chloramphénicol sur le sommeil du chat —Comparaison avec le thiamphénicol, l'érythromycine et l'oxytétracycline

  • Françoise Petitjean
  • Colette Buda
  • Michèle Janin
  • Marcel David
  • Michel Jouvet
Original Investigations

The effect of chloramphenicol on sleep in cat —Comparison with thiamphenicol, erythromycine, and oxytetracycline

Abstract

The effects of various antibiotics, which inhibit protein synthesis, has been studied on the sleepwaking cycle of cats. Chloramphenicol (CAP) selectively inhibits paradoxical sleep (SP). Thiamphenicol (TAP) and oxytetracycline however are ineffective; erythromycine induces only a small decrease of SP. When CAP is injected after TAP, the SP inhibition is longer than after CAP alone. Combining erythromycine and CAP produces the same effect as one or other of the antibiotic alone, depending only on the interval between administration of the two drugs. Slow wave sleep is decreased only with high doses of CAP and is unaffected by TAP, oxytetracycline or erythromycine. These results suggest that CAP may inhibit a peptide or protein synthesis involved in the mechanisms of SP.

Key words

Chloramphenicol Erythromycine Oxytetracycline Thiamphenicol Sleep-waking cycle Paradoxical sleep 

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Copyright information

© Springer-Verlag 1979

Authors and Affiliations

  • Françoise Petitjean
    • 1
  • Colette Buda
    • 1
  • Michèle Janin
    • 1
  • Marcel David
    • 1
  • Michel Jouvet
    • 1
  1. 1.Département de Médecine expérimentaleUniversité Claude-BernardLyon Cedex 2France

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