Effects of ethyl alcohol on behaviour in nursing female mice
- 14 Downloads
Effects of administering 10% ethyl alcohol as drinking fluid to mice during pregnancy and lactation have been examined by ethological analysis of behaviour of nursing females in their home cages at 1 day, 5–7 days and 12–14 days postpartum. The treatment with alcohol did not affect gestation period or litter size, and fluid intake of treated mice remained similar to that of controls, the average intake of alcohol amounting to 29 mg/g body weight during lactation.
Increase in frequency of exploration at 1 day postpartum was the only significant behavioural effect of alcohol on the nursing female mice. Duration of Non-Social Behaviour was unaltered, and no effects of the treatment on Maternal Behaviour or on Social and Sexual Investigation of male partners could be demonstrated.
Behaviour of nursing females changed with increase in age of their pups. This occurred to a similar extent in treated and control animals. Maternal and Non-Social Behaviours declined in frequency as the pups became older although the time spent in these behaviours remained fairly constant. Social Investigation of the male partner declined both in frequency and duration while females were nursing their pups.
Key wordsEthyl alcohol Maternal behaviour Mouse
Unable to display preview. Download preview PDF.
- Abel, E. L.: Effects of ethanol on pregnant rats and their offspring. Psychopharmacology 57:5–11 (1978)Google Scholar
- Anthony, E.: The child and his family, Vol. II. New York: Wiley 1973Google Scholar
- Barry, R. G. G., O'Nuallain, S.: Foetal alcoholism. Irish J. Med. Sci. 144, 286–288 (1975)Google Scholar
- Branchey, L., Friedhoff, A. J.: Biochemical and behavioural changes in rats exposed to ethanol in utero. Ann. N. Y. Acad. Sci. 273, 328–330 (1976)Google Scholar
- Cutler, M. G., Ewart, F. G., Mackintosh, J. M.: Growth and behavioural effects of ethyl alcohol on the offspring of mice; a comparison with its short-term actions. Psychopharmacology (in press, 1979)Google Scholar
- Elis, J., Krsiak, N.: Effect of alcohol administration during pregnancy on social behaviour of offsprings of mice. Act. Nerv. Super (Praha) 17, 281–282 (1975)Google Scholar
- Ewart F. G., Cutler, M. G.: Effects of alcohol administration on development and social behaviour in the offspring of laboratory mice. Pschopharmacology 62, 247–251 (1979)Google Scholar
- Jones, K. L., Smith, D. W., Ulleland, C. N., Streissguth, A. P.: Pattern of malformation in offspring of chronic alcoholic mothers. Lancet 1973II, 1267–1271Google Scholar
- Lee, M. M. S., Williams, D. I.: A longitudinal study of mother-young interaction in the rat: The effects of infantile stimulation, diurnal rhythms and pup maturation. Behaviour 63, 241–261 (1977)Google Scholar
- Mackintosh, J. M., Chance, M. R. A., Silverman, A. P.: The contribution of ethological techniques to the study of drug effects. In: Handbook of psychopharmacology, Vol. 7, L. I. Iverson, S. D. Iverson, S. M. Snyder, eds., pp. 3–35. New York: Plenum 1977Google Scholar
- Moltz, M.: The ontogeny of maternal behaviour in some selected mammalian species. In: The ontogeny of vertebrate behaviour. M. Moltz, ed., pp. 263–313. New York: Academic Press 1971Google Scholar
- Noirot, E.: Ultrasons et comportements maternels chez les petits rongeurs. Ann. Soc. Roy. Zool. Belg. 95, 47–56 (1966)Google Scholar
- Noirot E., Pye, J. D.: Sound analysis of ultrasonic distress calls of mouse pups as a function of their age. Anim. Behav. 17, 340–349 (1969)Google Scholar
- Noirot, E.: The onset of maternal behaviour in rats, hamsters and mice. A selective review. Adv. Stud. Behav. 4, 107–145 (1972)Google Scholar
- Reisbick, S., Rodenblatt, J. S., Mayer, A. D.: Decline of maternal behaviour in the virgin and lactating rat. J. Comp. Physiol. Psychol. 89, 722–732 (1975)Google Scholar
- Rhingold, M. L.: Maternal behaviour in mammals. New York: Wiley 1963Google Scholar
- Yanai, J., Ginsburg, B. E.: Long-term reduction of male agonistic behaviour in mice following early exposure to ethanol. Psychopharmacology 52, 31–34 (1977)Google Scholar