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Psychopharmacology

, Volume 47, Issue 3, pp 267–269 | Cite as

Cross tolerance to antinociception elicited by intracerebroventricular administration of mescaline and morphine to rabbits, and EEG correlates

  • S. Ferri
  • A. Santagostino
  • P. C. Braga
Animal Studies

Abstract

Tolerance and cross tolerance to the antinociceptive effect of equipotent doses of morphine (10 μg/kg) and mescaline (100 μg/kg) are shown in the rabbit after their repeated intracerebroventricular administration. The recording of the electrical activity of different brain areas indicates that a partial tolerance also develops to the EEG effects in animals undergoing chronic treatment with mescaline.

The comparison of certain of the mescaline-induced effects with those of morphine suggests that some biochemical and neural patterns are common to the 2 drugs.

Key words

Mescaline Morphine Nociception EEG 

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Copyright information

© Springer-Verlag 1976

Authors and Affiliations

  • S. Ferri
    • 1
  • A. Santagostino
    • 1
  • P. C. Braga
    • 1
  1. 1.Institute of Pharmacology, Laboratory of Applied Pharmacology, Faculty of SciencesUniversity of MilanItaly

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