Abstract
The interference of chlorpromazine (CPZ) and several preincubated CPZ metabolites on the lymphocyte absorption of antibodies directed against HLA-A1 and other nonrelated HLA specificities were investigated. Both CPZ and metabolites 7-OH-, Nor1-, and Nor2-CPZ were found to interfere with the specific absorption of anti-HLA-A1 antibodies. The meaning of such a result is discussed.
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Bernoco, D., Mattiuz, P. L., Miggiano, V. C., Ceppellim, R.: Turnover of HLA antigens at the lymphocyte surface. G. Batteriol. Virol. Immunol. 14, 272–284 (1971)
Bhandari, S. C., Singal, B. P.: Removal and regeneration of HLA antigens on peripheral blood lymphocytes. Tissue Antigens 3, 140–143 (1973)
Boyum, A.: Separation of lymphocytes and erythrocytes by centrifugation. Scand. J. Clin. Lab. Invest. 97, 1–109 (1968)
Buckley, J. P., Steenberg, M. L., Barry, H., Manian, A. A.: Pharmacological and behavioural effects of mono- and disubstituted chlorpromazine derivatives. In: Phenothiazines and structurally related drugs, I. S. Forrest, C. J. Carr, E. Usdin, eds., pp. 617–625. New York: Raven 1974
Corsini, G. U., Del Zompo, M., Manconi, S., Cianchetti, C., Mangoni, A., Gessa, G. L.: Non-striatal dopaminergic neurons. In: Advances in biochemical psychopharmacology, vol. 16, G. L. Gessa, E. Costa, eds., pp. 645–648, New York: Raven 1977
Curry S. H.: Metabolism and kinetics of chlorpromazine in relation to effect. In: Antipsychotic drugs: Pharmacodynamics and pharmacokinetics, G. Sedvall, B. Uvnas, Y. Zotterman eds., pp. 343–352. New York: Pergamon 1976
Mittal, K. K., Mickey, M. R., Singal D. P., Terasaki, P. L.: Serotyping for homotransplantation. Refinement of microdroplet lymphocyte cytotoxicity test. Transplantation 6, 913–927 (1968)
Miyajima, T., Hirata, A. A., Terasaki, P. L.: Escape from sensitization to HLA antibodies. Tissue Antigens 2, 64–73 (1972)
Scorza-Smeraldi, R., Smeraldi, E., Fabio, G., Bellodi, L., Sacchetti, E., Rugarli, C.: Interference between anti-HLA-antibodies and adrenergic receptor binding drugs. Tissue Antigens 9, 163–166 (1977)
Smeraldi, E., Scorza-Smeraldi, R.: Interference between HLA antibodies and chlorpromazine. Nature 260, 532–533 (1976)
Smeraldi, E., Bellodi, L., Sacchetti, E., Cazzullo, C. L.: The HLA system and the clinical response to treatment with chlorpromazine. Br. J. Psychiatry 129, 486–489 (1976)
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Smeraldi, E., Scorza-Smeraldi, R., Fabio, G. et al. Interference between anti-HLA antibodies and CPZ metabolites. Psychopharmacology 67, 87–89 (1980). https://doi.org/10.1007/BF00427600
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DOI: https://doi.org/10.1007/BF00427600