Abstract
The effect of low doses (7.5–250 μg/kg) of d-amphetamine was studied on benztropine- or γ-butyrolactone-induced hyperactivity in the mouse. Amphetamine 30–125 μg/kg significantly attenuated the drug-induced hyperactivity. This effect was antagonised by both cinanserin and p-chlorophenylalanine. The results suggest that low doses of d-amphetamine release 5-hydroxytryptamine, which in turn has an inhibitory effect on locomotor activity. This effect was masked at higher doses of d-amphetamine due to a release of dopamine.
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Hussey, J.S., Vincent, N.D. & Davies, J.A. The effect of low doses of d-amphetamine on drug-induced hyperactivity in the mouse. Psychopharmacology 81, 327–331 (1983). https://doi.org/10.1007/BF00427571
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DOI: https://doi.org/10.1007/BF00427571