Skip to main content
Log in

The effect of low doses of d-amphetamine on drug-induced hyperactivity in the mouse

  • Original Investigations
  • Published:
Psychopharmacology Aims and scope Submit manuscript

Abstract

The effect of low doses (7.5–250 μg/kg) of d-amphetamine was studied on benztropine- or γ-butyrolactone-induced hyperactivity in the mouse. Amphetamine 30–125 μg/kg significantly attenuated the drug-induced hyperactivity. This effect was antagonised by both cinanserin and p-chlorophenylalanine. The results suggest that low doses of d-amphetamine release 5-hydroxytryptamine, which in turn has an inhibitory effect on locomotor activity. This effect was masked at higher doses of d-amphetamine due to a release of dopamine.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Carter CJ, Pycock CJ (1978) Differential effects of central serotonin manipulation on hyperactive and stereotyped behaviour. Life Sci 23:953–960

    Google Scholar 

  • Cheramy A, Gauchy G, Glowinski J, Besson MJ (1973) In vivo activation by benztropine of dopamine release and synthesis in the caudate nucleus. Eur J Pharmacol 21:246–248

    Google Scholar 

  • Cole SO (1978) Brain mechanisms of amphetamine-induced anorexia, locomotion and stereotypy: A review. Neurosci Biobehav Rev 2:89–100

    Google Scholar 

  • Costall B, Gui S-CG, Naylor RJ (1979) The importance of serotonergic mechanisms for the induction of hyperactivity by amphetamine and its antagonism by intra-accumbens (3,4-dihydroxyphenylalamine)-2-imidazoline (DPI). Neuropharmacology 18:605–609

    Google Scholar 

  • Davies JA (1978) The effect of gamma-butyrolactone on locomotor activity in the rat. Psychopharmacology 60:67–72

    Google Scholar 

  • Davies JA, Williams J (1983) A role for 5-hydroxytryptamine in the GABA-mimetic potentiation of α-flupenthixol-induced catalepsy in the rat. Br J Pharmacol 78:137–142

    Google Scholar 

  • Ennis C, Kemp JD, Cox B (1981) Characterization of inhibitory 5-hydroxytryptamine receptors that modulate dopamine release in the striatum. J Neurochem 36:1515–1520

    Google Scholar 

  • Geyer MA, Puerto A, Menkes DB, Segal DS, Mandell AJ (1976) Behavioural studies following lesions of the mesolimbic and mesostriatal serotonergic pathways. Brain Res 106:257–270

    Google Scholar 

  • Heffner TG, Seiden LS (1982) Possible involvement of serotonergic neurones in the reduction of locomotor hyperactivity caused by amphetamine in neonatal rats depleted of brain dopamine. Brain Res 244:81–90

    Google Scholar 

  • Holmes JC, Rutledge CO (1976) Effects of D- and L-isomers of amphetamine on uptake, release and catabolism of norepinephrine, dopamine, and 5-hydroxytryptamine in several regions of rat brain. Biochem Pharmacol 25:447–451

    Google Scholar 

  • Hutchins DA, Rayeusky KS, Sharman DF (1972) The effect of sodium gamma-hydroxybutyrate on the metabolism of dopamine in the brain. Br J Pharmacol 46:409–415

    Google Scholar 

  • Kelly P, Seviour P, Iversen S (1975) Amphetamine and apomorphine responses in the rat following 6-hydroxydopamine lesions of the nucleus accumbens septi and corpus striatum. Brain Res 94:507–522

    Google Scholar 

  • Mantel N, Voland RS (1970) A technique of non-parametric multivariate analysis. Biometrics 26:546–558

    Google Scholar 

  • Myers HM, Musty RE, Hendley ED (1982) Attenuation of hyperactivity in the spontaneously hypertensive rat by amphetamine. Behav Neural Biol 34:42–54

    Google Scholar 

  • Walters JR, Roth RH, Aghajanian GK (1973) Dopaminergic neurones. Similar biochemical and histochemical effects of γ hydroxybutyrate and acute lesions of the nigroneostriatal pathway. J Pharmacol Exp Ther 186:630–639

    Google Scholar 

  • Westfall TC, Besson MJ, Gioguieff MF, Glowinski J (1976) The role of presynaptic receptors in the release and synthesis of 3H-dopamine by slices of rat striatum. Naunyn-Schmiedeberg's Arch Pharmacol 292:279–287

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hussey, J.S., Vincent, N.D. & Davies, J.A. The effect of low doses of d-amphetamine on drug-induced hyperactivity in the mouse. Psychopharmacology 81, 327–331 (1983). https://doi.org/10.1007/BF00427571

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00427571

Key words

Navigation