, Volume 80, Issue 1, pp 14–18 | Cite as

Tricyclic plasma levels in depressed outpatients treated with amitriptyline

  • Karl Rickels
  • Charles Weise
  • George Case
  • Howard Hucker
Original Investigations


Seventy-four patients were treated with 150 mg/day amitriptyline (AT) to determine possible correlations between clinical improvement, demographic variables, and AT and nortriptyline (NT) plasma levels. Plasma level determinations after 2 and 6 weeks of treatment revealed that moderately significant correlations existed between AT plasma levels and clinical improvement, dosage intake, age, weight, sex, and coffee intake. Some of these findings were more pronounced after 2, and some after 6 weeks of treatment.

Key words

Tricyclic antidepressant Plasma level Amitriptyline Nortriptyline Clinical improvement Depression Psychopathology 


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Copyright information

© Springer-Verlag 1983

Authors and Affiliations

  • Karl Rickels
    • 1
  • Charles Weise
    • 1
  • George Case
    • 1
  • Howard Hucker
    • 2
  1. 1.Department of Psychiatry, Psychopharmacology Research and Treatment Unit and Private Practice Research GroupUniversity of PennsylvaniaPhiladelphiaUSA
  2. 2.Merck, Sharp and DohmeWest PointUSA

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