, Volume 84, Issue 2, pp 188–195 | Cite as

The effect of acute zimeldine and alaproclate administration on the acquisition of two-way active avoidance: Comparison with other antidepressant agents, test of selectivity and sub-chronic studies

  • Trevor Archer
  • Sven-Ove Ögren
  • Göran Johansson
  • Svante B. Ross
Original Investigations


The dose-dependent effect of acute zimeldine and alaproclate treatment upon the acquisition of two-way and one-way active avoidance in the rat was studied in a single-session and in a repeated-sessions design. Zimeldine (5–20 mg/kg, IP), but not alaproclate, caused disruptions of two-way avoidance acquisition. Acquisition deficits were also caused by citalopram and fluoxetine but not the other antidepressant drugs tested. Zimeldine, but not alaproclate or desipramine, caused a slight but non-significant impairment of one-way active avoidance; neither zimeldine nor alaproclate produced any effects upon fear conditioning and retention testing. The long-term action of p-chloroamphetamine (2×10 mg/kg) antagonised the acute zimeldine effect totally, and chronic treatment with zimeldine (15 days, 1×50 μmol/kg) and chlorimipramine (15 days, 2×10 μmol/kg) also caused some partial blockade of the two-way avoidance deficit. These data seem to suggest some involvement of serotonin (5-HT) in the observed disruptions of two-way active avoidance caused by acute zimeldine treatment.

Key words

Zimeldine Alaproclate Antidepressants PCA Selectivity Subchronic administration Two-way One-way Avoidance Rat 


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Copyright information

© Springer-Verlag 1984

Authors and Affiliations

  • Trevor Archer
    • 1
  • Sven-Ove Ögren
    • 1
  • Göran Johansson
    • 1
  • Svante B. Ross
    • 1
  1. 1.Research and Development LaboratoriesAstra Läkemedel ABSödertäljeSweden

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