, Volume 83, Issue 1, pp 104–106 | Cite as

Absolute bioavailability of imipramine: Influence of food

  • Darrell R. Abernethyl
  • Marcia Divoll
  • David J. Greenblatt
  • Jerold S. Harmatz
  • Richard I. Shader
Original Investigations


Imipramine hydrochloride (IMI) was administered to 12 healthy volunteers on three occasions in random sequence: 12.5 mg IV, 50 mg orally after overnight fast, and 50 mg orally 30 min after eating a standardized breakfast. IMI concentrations were measured by gas-liquid chromatography using nitrogen-phosphorous detection and pharmacokinetic and bioavailability parameters determined by iterative nonlinear least-squares regression analysis. After IV administration, mean kinetic variables were: volume of distribution, 21.0 l/kg; total clearance, 12.8 ml/min per kg, and elimination half-life, 21.2 h. Mean absolute bioavailability of IMI in the fasting state was 43.6%. When IMI was administered immediately after the standardized meal, absolute bioavailability was 44.1%. After oral administration, the time to peak IMI level was not changed by concurrent food ingestion (2.8 vs 3.2 h after dosage), and the peak IMI concentration was no different (35 vs 30 ng/ml). Thus concurrent food ingestion has no effect on IMI absolute bioavailability, peak concentration attained after oral dosing, or the time to peak concentration.

Key words

Imipramine Antidepressants Pharmacokinetics Bioavailability Food interaction 


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Copyright information

© Springer-Verlag 1984

Authors and Affiliations

  • Darrell R. Abernethyl
    • 1
  • Marcia Divoll
    • 1
  • David J. Greenblatt
    • 1
  • Jerold S. Harmatz
    • 1
  • Richard I. Shader
    • 1
  1. 1.Division of Clinical Pharmacology, Departments of Psychiatry and MedicineTufts University School of Medicine, New England Medical Center HospitalBostonUSA

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