Psychopharmacology

, Volume 83, Issue 1, pp 79–81 | Cite as

Effect of diazepam on plasma corticosterone levels

  • Danka Peričić
  • Nela Lakić
  • Hari Manew
Original Investigations

Abstract

In light of the numerous but rather conflicting reports on the action of benzodiazepines upon the hypothalamo-hypophyseal-adrenal (HHA) axis activity, the effect of different doses of diazepam (0.1, 1.0 and 10.0 mg/kg) administered 15, 30, 60, 120 and 240 min before decapitation on plasma corticosterone level was studied in rats. While 0.1 mg/kg diazepam had no effect, 1.0 mg/kg diazepam decreased plasma corticosterone levels 30 and 60 min following drug administration. On the other hand, treatment with 10.0 mg/kg diazepam produced an increase in plasma corticosterone levels from 15–120 min following drug administration.

Key words

Diazepam Plasma corticosterone 

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Copyright information

© Springer-Verlag 1984

Authors and Affiliations

  • Danka Peričić
    • 1
  • Nela Lakić
    • 1
  • Hari Manew
    • 1
  1. 1.Department of Experimental Biology and MedicineRudjer Bošković InstituteZagrebYugoslavia

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