, Volume 58, Issue 3, pp 229–233 | Cite as

Effects of l-tryptophan and ethanol on sleep parameters in the rat

  • Shirley Y. Hill
  • Renato B. Reyes


Sleep parameters were monitored following (1) a single 2 g/kg oral dose of ethanol, (2) an oral dose of l-tryptophan (600 mg/kg), and (3) administration of both drugs simultaneously. Ethanol reduced REM and increased slow wave significantly. The effects of l-tryptophan were apparent only in the case of one parameter, REM latency. Administration of both drugs resulted in a significantly shorter REM latency than that observed for ethanol administered alone. Results are discussed in terms of possible changes in the biosynthesis of 5-HT.

Key words

Ethanol l-Tryptophan Sleep Drug effects 5-HT neurons Rats 


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Copyright information

© Springer-Verlag 1978

Authors and Affiliations

  • Shirley Y. Hill
    • 1
  • Renato B. Reyes
    • 1
  1. 1.Department of PsychiatryWashington University School of MedicineSt. LouisUSA

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