Abstract
A prominent effect of ethanol is on rectal body temperature. The use of a rectal probe to measure temperature can be stressful to the subject, especially when used repeatedly. We now present data on the hypothermic effect of ethanol (0.5, 1.0, 3.0, 3.5, or 4.0 g/kg) on surface body temperature in rats as detected by infrared radiation. Ethanol produced significant decreases in nasal temperature that were significantly correlated with changes in rectal temperature. Ethanol (3.5 g/kg) also produced a significant reversal in nasal hypothermia 15 min postinjection that was detected only with the infrared method. This new method is very rapid, accurate, requires minimal handling and may, therefore, be less stressful than rectal measurement to the subject.
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References
Antoon J, Gregg R (1976) The influence of body temperature on the production of ulcers of restraint in the rat. Gastroenterology 70:747–750
Brick J, Pohorecky L (1977) Ethanol withdrawal: Altered ambient temperature selection in rats. Alcohol Clin Exp Res 1:207–211
Crabbe JD, Righter H, Uijlen J, Stribos C (1979) Rapid development of tolerance to the hypothermic effect of ethanol in mice. J Pharmacol Exp Ther 208:128–133
Fewings JD, Hanna MJD, Walsh JA, Whelan RF (1966) The effects of ethyl alcohol on the blood vessels of the hand and forearm in man. Br J Pharmacol Chemother 26:93–106
Fox G, Hayward J, Hobson G (1979) Effect of alcohol on thermal balance of man in cold water. Can J Physiol Pharmacol 57:860–865
Freund G (1973) Hypothermia after acute ethanol and benzyl alcohol administration. Life Sci 13:345–349
Gillespie JA (1967) Vasodilator properties of alcohol. Br Med J 2:274–277
Graf K, Strom G (1960) Effect of ethanol ingestion on arm blood flow in healthy young men at rest and during leg work. Acta Pharmacol Toxicol (Copenh) 17:115–120
Keppel G (1973) Design and analysis: A researcher's handbook. Prentice Hall, Englewood Cliffs, NJ, pp 87–88
Poole S, Stephenson JD (1979) Effects of noradrenaline and carbachol on temperature regulation of rats. J Pharmacol 65:43–51
Ritzmann RF, Tabakoff B (1976) Body temperature in mice: A quantitative measure of alcohol tolerance and physical dependence. J Pharmacol Exp Ther 199:158–170
Stewart J, Eikelboom R (1979) Stress masks the hypothermic effects of naloxone in rats. Life Sci 25:1165–1172
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Brick, J., Pohorecky, L.A. Effect of ethanol on surface body temperature as measured by infrared radiation detection. Psychopharmacology 81, 244–246 (1983). https://doi.org/10.1007/BF00427271
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DOI: https://doi.org/10.1007/BF00427271