Virchows Archiv A

, Volume 384, Issue 2, pp 185–193 | Cite as

Ovarian sex cord tumor with annular tubules

Clinicopathologic report of two benign and one malignant cases with long follow-ups
  • E. Gloor
Original Articles


The clinicopathologic features of three new cases of ovarian sex cord tumors with annular tubules are presented, thereby increasing to 23 the number of the published cases in the world literature. These three observations, along with another one which was previously published, were found in the files of the Institute of Pathology of the University of Lausanne from 1939 to 1978. Forty-seven granulosa cell tumors and eight Sertoli and/or Leydig cell tumors of the ovary were found during the same 40-year period. The patients were 48, 64 and 71 years of age. No sign of the Peutz-Jeghers syndrome was noticed in the three patients. All three tumors caused metrorrhagias as a cardinal sign. They were bulky, unilateral and were formed by solid tissue with cystic spaces. Histologically, the most characteristic pattern consisted of simple and complex tubular structures as described by Scully in 1970. Two patients, in which the mitotic indexes of the tumors were lower than 5 mitoses per 10 HPF, died without evidence of a recurrence 36 and 37 years after surgical ablation of the tumor. The third patient, whose neoplasm featured fewer well differentiated tubular structures than the two previous ones and had a mitotic index of over 70 mitoses per 10 HPF, died from massive abdominal recurrence after 5 years and 5 months.

Key words

Ovarian neoplasms Pathology 


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  1. Costa, J.: Peutz-Jeghers syndrome. Case presentation. Obstet. Gynecol. 50, 15S-17S (1977)Google Scholar
  2. Gloor, E.: Un cas de syndrome de Peutz-Jeghers associé à un carcinome mammaire bilatéral, à un adénocarcinome du col utérin et à des tumeurs des cordons sexuels à tabules annelés bilatérales dans les ovaires. Schweiz. Med. Wochenschr. 108, 717–721 (1978)Google Scholar
  3. Gondos, B., Monroe, S.A.: Cystic granulosa cell tumor with massive hemoperitoneum. Light and electron microscopic study. Obstet. Gynecol. 38, 683–689 (1971)Google Scholar
  4. Hertel, B.F., Kempson, R.L.: Ovarian sex cord tumors with annular tubules: an ultrastructural study. Am. J. Surg. Pathol. 1, 145–153 (1977)Google Scholar
  5. Netter Lambert, A., Yaneva, H., Coudouel, S., Netter, A., Allaneau, C., Seringe, P.: Tumeur ovarienne et syndrome de Peutz-Jeghers. Un nouveau cas féminin de tumeur malformative des cordons sexuels. Ann. Méd. Interne 124, 187 (1973)Google Scholar
  6. Norris, H.J., Garner, F.M., Taylor, H.B.: Comparative pathology of ovarian neoplasms. IV. Gonadal stromal tumours of canine species. J. Comp. Pathol. 80, 399–405 (1970)Google Scholar
  7. Norris, H.J., Chorlton, I.: Functioning tumors of the ovary. Clin. Obstet. Gynecol. 17, 189–228 (1974)Google Scholar
  8. Scully, R.E.: Sex cord tumor with annular tubules. A distinctive ovarian tumor of the Peutz-Jeghers syndrome. Cancer 25, 1107–1121 (1970)Google Scholar
  9. Scully, R.E.: Sex cord-stromal tumors. In: Pathology of the female genital tract (Blaustein, A., Ed.) p. 505–526. New York-Heidelberg-Berlin: Springer 1977Google Scholar
  10. Scully, R.E.: Ovarian tumors. A review. Am. J. Pathol. 87, 686–720 (1977)Google Scholar
  11. Steenstrup, E.K.: Ovarian tumours and Peutz-Jeghers syndrome. A case of “Sex cord tumour with annular tubules” (Scully). Acta Obstet. Gynecol. Scand. 51, 237–240 (1972)Google Scholar
  12. Sternberg, W.H., Dhurandhar, H.N.: Functional ovarian tumors of stromal and sex cord origin. Hum. Pathol. 8, 565–582 (1977)Google Scholar
  13. Waisman, J., Lischke, H.J., Mwasi, L.M., Dignam, W.J.: The ultrastructure of a feminizing granulosa-theca tumor. Am. J. Obstet. Gynecol. 123, 147–150 (1975)Google Scholar

Copyright information

© Springer-Verlag 1979

Authors and Affiliations

  • E. Gloor
    • 1
  1. 1.Institute of PathologyUniversity of Lausanne, C.H.U.V.LausanneSwitzerland

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