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Psychopharmacology

, Volume 62, Issue 2, pp 151–155 | Cite as

Every-other-day acetylmethadol disturbs circadian cycles of human motility

  • Thomas J. Crowley
  • Richard H. Jones
  • Marilyn J. Hydinger-Macdonald
  • James R. Lingle
  • Janice E. Wagner
  • Donald J. Egan
Original Investigations

Abstract

1-Alpha-acetylmethadol (LAAM) maintenance treatment has been proposed as a favorable alternative to methadone maintenance. With an un-obtrusive actometer we recorded two successive 24-h cycles of spontaneous motor activity from 12 patients receiving LAAM every other day, and from five receiving methadone every day. LAAM patients were about 50% more active on days of drug administration than on no-dose days (P<0.001). There were no significant day-to-day differences in motility of methadone patients. LAAM administered every other day may significantly modify the human circadian rhythm of spontaneous motility; further research is thus needed before this treatment is widely akopted.

Key words

Acetylmethadol Methadone Motility Circadian rhythm Drug abuse Human behavior 

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Copyright information

© Springer-Verlag 1979

Authors and Affiliations

  • Thomas J. Crowley
    • 1
  • Richard H. Jones
    • 2
  • Marilyn J. Hydinger-Macdonald
    • 1
  • James R. Lingle
    • 1
  • Janice E. Wagner
    • 3
  • Donald J. Egan
    • 3
  1. 1.Department of PsychiatryUniversity of Colorado Medical CenterDenverUSA
  2. 2.Department of BiometricsUniversity of Colorado Medical CenterDenverUSA
  3. 3.Department of Addiction Research and Treatment ServicesUniversity of Colorado Medical CenterDenverUSA

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