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Effects of LSD-25 on avoidance behavior and locomotor activity in mice

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Abstract

C57BL/6 (C57) mice were tested in a shuttle box under the influence of LSD-25 in two sets of experiments.

In the first set, the pretrial administrations of LSD (0.05, 0.1, and 0.2 mg/kg) were followed by dose-related performance improvements. In the second set, the posttrial administration of LSD (0.2 mg/kg) immediately after each experimental session improved the performances of the mice. No effect was evident when the hallucinogen was injected 2 h after training, thus showing that LSD improved the memory processes of the C57 mice in these experimental conditions.

Dose-related activity depressant effects were evident in a third set of experiments, carried out in a toggle-floor box.

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  1. Laboratorio di Psicobiologia e Psicofarmacologia del C. N. R., Via Reno 1, I-00198, Roma, Italy

    Claudio Castellano

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  1. Claudio Castellano
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Castellano, C. Effects of LSD-25 on avoidance behavior and locomotor activity in mice. Psychopharmacology 62, 145–149 (1979). https://doi.org/10.1007/BF00427128

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  • DOI: https://doi.org/10.1007/BF00427128

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