Virchows Archiv A

, Volume 362, Issue 4, pp 331–342 | Cite as

Early morphological alterations of the rat lung with increased intracranial pressure

I. A light and electron microscopic study
  • Harald Hücker
  • Ulrich Schäfer
  • Klaus Meinen


Ultrastructural alterations of the rat lung following marked increase in intracranial pressure involve interstitial and intraalveolar hemorrhagic and proteinous edema accumulation developing within a few minutes. Capillary endothelium reveals intracellular bleb formations, scallops, and increased pinocytic activity. There is no separation of intercellular junctions both in endothelium and epithelium of the alveolar wall. The common basement membrane of the air-blood-barrier seems to be intact, whereas type I pneumonocyte of the alveolar epithelium shows similar bleb formations as the endothelium. Type II pneumonocyte elicits imposing cytoplasmic protrusions. Edema fluid contains electron dense components and washes out surface active lining layer of lung alveoli.


Intracranial Pressure Morphological Alteration Alveolar Epithelium Alveolar Wall Intercellular Junction 
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Copyright information

© Springer-Verlag 1974

Authors and Affiliations

  • Harald Hücker
    • 1
  • Ulrich Schäfer
    • 1
  • Klaus Meinen
    • 1
  1. 1.Institut für allgemeine und experimentelle Pathologie der Bundeswehr in MainzFederal Republic of Germany

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