Advertisement

Virchows Archiv A

, Volume 362, Issue 4, pp 311–314 | Cite as

Testicular lesions in rats treated for one year with ethambutol in low doses

  • G. P. Trentini
  • A. Botticelli
  • G. Barbolini
Article

Summary

EMB administered to albino rats in therapeutic doses for one year caused not only the loss of fertility but also evident regressive lesions in the testes. The phenomenon may be attributed to the chemical nature of dextrorotatory isomer of EMB or on the other hand to accumulation of the drug in the organism.

Keywords

Public Health Therapeutic Dose Chemical Nature Ethambutol Testicular Lesion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Botticelli, A., Trentini, G.P., Barbolini, G.: Lesioni testioolari nel ratto trattato con etambutolo. Boll. Soc. ital. Biol. sper. 47, 72–75 (1971)Google Scholar
  2. Cappiello, V.P., Layton, W.M., Jr.: A one-year study of toxicology of ethambutol in dogs; results of gross and histopathologic examinations. Toxicol. appl. Pharmacol. 7, 844–849 (1965)Google Scholar
  3. Diermeier, H.F., Kaiser, J.A., Yuda, N.: Safety evaluation of ethambutol. Ann. N.Y. Acad. Sci. 135, 732–746 (1966)Google Scholar
  4. Kaiser, J. A.: Toxicology of ethambutol: long term studies in dogs. Pharmacologist 4, 176–179 (1962)Google Scholar
  5. Kaiser, J.A.: A one-year study of the toxicity of ethambutol in dogs: results during life. Toxicol. appl. Pharmacol. 6, 557–567 (1964)Google Scholar
  6. Lucchesi, M., Zubiani, M., Termine, A., Rossi, P.: Concentrazioni sieriche dell' etambutolo in pazienti trattati con diverse modalità e dosaggi. Ann. Ist. Forlanini 26, 61–69 (1966)Google Scholar

Copyright information

© Springer-Verlag 1974

Authors and Affiliations

  • G. P. Trentini
    • 1
  • A. Botticelli
    • 1
  • G. Barbolini
    • 1
  1. 1.Istituto di Anatomia e Istologia Patologica dell'Università di ModenaModenaItaly

Personalised recommendations