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The caloric and intoxicating properties of fluid intake as components of stress-induced ethanol consumption in rats

Psychopharmacology volume 57, pages 27–31 (1978)Cite this article

Abstract

Rats housed continuously in a test environment for 25 days were offered water, 5% v/v ethanol, 10% v/v ethanol, and propylene glycol at 7.5% w/v. The propylene glycol concentration represented a caloric midpoint between the 5 and 10% ethanol. After 10 baseline sessions, during which preference for the four solutions was shown to be statistically equal, shock schedules were introduced. The consumption of ethanol at both concentrations showed significant peaks for the interval immediately following 12 min of shock each hour. Intake peaks were not observed for the water or propylene glycol. Baseline blood alcohol levels were negligible, but blood levels under shock averaged 143 mg/dl and ranged from 45.0 mg/dl to 295.0 mg/dl. After the shock sessions were terminated, baseline drinking indicated no significant change in preference relative to pre-shock baselines, but there was an elevation in preference for 5% ethanol relative to the other fluids. The preference for propylene glycol or water did not change.

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References

  • Allison, J.: Microbehavioral features of nutritive and non-nutritive drinking in rats. J. Comp. Physiol. Psychol. 76(3), 408–417 (1971)

    Google Scholar 

  • Berman, R. F., Cannon, D. S.: The effect of prior ethanol experience on ethanol-induced saccharin aversions. Physiol. Behav. 12, 1041–1044 (1974)

    Google Scholar 

  • Best, M. R.: Conditioned and latent inhibition in taste-aversion learning: clarifying the role of learned safety. J. Exp. Psychol. 104(2), 97–113 (1975)

    Google Scholar 

  • Booth, D. C., Lovett, D., McSherry, G. M.: Postingestive modulation of the sweetness preference gradient in the rat. J. Comp. Physiol. Psychol. 78(3), 485–512 (1972)

    Google Scholar 

  • Cappell, H., Herman, P.: Alcohol and tension reduction: a review. Q. J. Stud. Alcohol 33, 33–64 (1972)

    Google Scholar 

  • Casey, A.: The effect of stress on the consumption of alcohol and reserpine. Q. J. Stud. Alcohol 21, 308–318 (1960)

    Google Scholar 

  • Eckardt, M. J.: Alcohol-induced conditioned taste aversion in rats: effect of concentration and prior exposure to alcohol. J. Stud. Alcohol 37, 334–346 (1976)

    Google Scholar 

  • Ellis, F. W., Hill, J. B.: An automated fluorometric procedure for the enzymatic determination of ethanol in fingertip blood. Clin. Chem. 15, 91–101 (1969)

    Google Scholar 

  • Freed, E. X., Lester, D.: Schedule induced consumption of ethanol: calories or chemotherapy? Physiol. Behav. 5, 555–560 (1970)

    Google Scholar 

  • Hulse, S.: Licking behavior of rats in relation to saccharin concentration and shifts in fixed ratio reinforcement. J. Comp. Physiol. Psychol. 64, 478–484 (1967)

    Google Scholar 

  • Hutcheson, J. S., Mills, K. C.: A compact and inexpensive drinkometer for use with small animals. Physiol. Behav. 13, 179–191 (1974)

    Google Scholar 

  • Lehman, A. J., Newman, H. W.: Propylene glycol: rate of metabolism absorption, and excretion, with a method for estimation in body fluids. J. Pharmacol. Exp. Ther. 60, 312–322 (1937)

    Google Scholar 

  • Lester, D.: Self-selection of alcohol by animals, human variation and the etiology of alcoholism. Q. J. Stud. Alcohol 27, 395–438 (1966)

    Google Scholar 

  • Lester, D., Freed, E.: Criteria for an animal model of alcoholism. Pharmacol. Biochem. Behav. 1, 103–107 (1973)

    Google Scholar 

  • Lester, D., Nachman, M., Le Magnen, J.: Aversive conditioning by ethanol in the rat. Q. J. Stud. Alcohol 31, 578–586 (1970)

    Google Scholar 

  • Mills, K. C., Bean, J. W., Hutcheson, J. S.: Shock induced ethanol consumption in the rat. Pharmacol. Biochem. Behav. 6, 107–115 (1977)

    Google Scholar 

  • Mook, D. G.: Saccharin preference in the rat: some unpalatable findings. Psychol. Rev. 81, 475–490 (1974)

    Google Scholar 

  • Myers, R. D., Holman, R.: Failure of stress of electric shock to increase ethanol intake in rats. Q. J. Stud. Alcohol 28, 132–137 (1967)

    Google Scholar 

  • Osol, A., Pratt, R.: The United States dispensatory. Philadelphia: J. B. Lippincott 1973

    Google Scholar 

  • Payne, D. W., Ellis, F. W.: An autoanalyzer II adaptation of an enzymatic determination of blood ethanol concentration. Advances in automated analysis. Tarrytown, New York: Mediad 1, 169–171 (1973)

    Google Scholar 

  • Ruddick, J. A.: Toxicology, metabolism and biochemistry of 1,2-propanediol. Toxicol. Appl. Pharmacol. 21, 102–111 (1972)

    Google Scholar 

  • Samson, H. H., Falk, J. L.: Alteration of fluid preference in ethanoldependent animals. J. Pharmacol. Exp. Ther. 190, 365–376 (1974)

    Google Scholar 

  • Stellar, E., Hill, J. H.: The rat's rate of drinking as a function of water deprivation. J. Comp. Physiol. Psychol. 45, 96–102 (1952)

    Google Scholar 

  • Valenstein, E. S.: Selection of nutritive and non-nutritive solutions under different conditions of need. J. Comp. Physiol. Psychol. 63, 429–433 (1967)

    Google Scholar 

  • Weast, R. C.: Handbook of chemistry and physics. The Chemical Rubber Co. Cleveland, Ohio 1962

    Google Scholar 

  • Winer, B. J.: Statistical principles in experimental design. New York: McGraw-Hill 1962

    Google Scholar 

Download references

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Authors and Affiliations

  1. Center for Alcohol Studies, Division of Health Sciences, University of North Carolina at Chapel Hill, 27514, North Carolina, USA

    K. C. Mills & J. W. Bean

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  1. K. C. Mills
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  2. J. W. Bean
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Mills, K.C., Bean, J.W. The caloric and intoxicating properties of fluid intake as components of stress-induced ethanol consumption in rats. Psychopharmacology 57, 27–31 (1978). https://doi.org/10.1007/BF00426953

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  • DOI: https://doi.org/10.1007/BF00426953

Key words

  • Stress
  • Alcohol
  • Consumption
  • Caloric controls
  • Propylene glycol