Psychopharmacology

, Volume 63, Issue 1, pp 29–32 | Cite as

Effects of chlordiazepoxide on maze performance of rats subjected to undernutrition in early life

  • J. M. Celedon
  • M. Colombo
Original Investigations

Abstract

The purpose of this research was to study the isolated effects of and interactions between undernutrition and emotional reactivity upon maze performance in rats. This work compares the effects of chlordiazepoxide on learning performance in two groups of adults rats: one undernourished early in life and then rehabilitated, and the other normally nourished. Chlordiazepoxide was used at 5 mg/kg body weight administered i.p. 30 min before each test. The response was evaluated in a Hebb-Williams maze. Water was used as reinforcement. Chlordiazepoxide improved performance in the early undernourished group 197±55.9 errors to 149±33.6 (mean±SD). Chlordiazepoxide impaired performance of the normal group from 107±22.7 errors to 197±42.2 errors. Analysis of variance gave an F=6.64, which is significant (P<0.01). This supports the hypothesis that the high emotional level of previously undernourished subjects acts negatively upon problem-solving performance.

Key words

Learning performance Chlordiazepoxide Hebb-Williams maze Undernutrition Rats 

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Copyright information

© Springer-Verlag 1979

Authors and Affiliations

  • J. M. Celedon
    • 1
  • M. Colombo
    • 1
  1. 1.Instituto de Nutricion y Tecnologia de los AlimentosUniversidad de ChileSantiago 11Chile

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