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Psychopharmacology

, Volume 57, Issue 2, pp 193–197 | Cite as

Neuroleptic drugs block both the hyperactivity and the increase in caudate nucleus cyclic AMP concentration produced by the administration of tranylcypromine and l-dopa to rats

  • D. J. Heal
  • A. R. Green
  • M. R. Bloomfield
  • D. G. Grahame-Smith
Original Investigations

Abstract

Injection of rats with tranylcypromine and l-dopa increased brain dopamine concentrations and produced a behavioural syndrome that includes hyper-activity. It also elevated caudate nucleus cyclic AMP concentrations by approximately 50% in vivo, probably by stimulating dopamine receptors. Pretreatment with chlorpromazine inhibited both the tranyl-cypromine/l-dopa-induced behaviour and elevated cyclic AMP concentrations in a dose-dependent manner. Haloperidol and α-flupenthixol also inhibited both effects, while β-flupenthixol and pimozide were without effect. Since none of these drugs altered the tranylcypromine/l-dopa-induced rise of brain dopamine, it is likely that they produced their effect by inhibiting dopamine-sensitive adenylate cyclase.

A good correlation was found to exist between the neuroleptic inhibition of both the increased behavioural activity and the increased caudate nucleus cyclic AMP concentrations produced by tranylcypromine and l-dopa.

Key words

Neuroleptics Cyclic AMP Caudate nucleus Dopamine Hyperactivity 

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Copyright information

© Springer-Verlag 1978

Authors and Affiliations

  • D. J. Heal
    • 1
    • 2
  • A. R. Green
    • 1
    • 2
  • M. R. Bloomfield
    • 1
    • 2
  • D. G. Grahame-Smith
    • 1
    • 2
  1. 1.MRC UnitRadcliffe InfirmaryOxfordUK
  2. 2.University Department of Clinical PharmacologyRadeliffe InfirmaryOxfordUK

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