, Volume 50, Issue 3, pp 309–312 | Cite as

Acquired preference for morphine but not d-amphetamine as a result of saccharine adulteration

  • Shirley Y. Hill
  • Barbara J. Powell
Animal Studies Short Report


Consumption of morphine sulfate and d-amphetamine was studied in two groups of rats. In a choice situation, preference for both drugs remained low after 46 days of drinking. In two additional groups morphine and d-amphetamine solutions were prepared with 1% saccharine. Morphine drinking was significantly increased by saccharine adulteration, whereas drinking of amphetamine solutions decreased. Addition of saccharine to morphine solutions increased drinking in more than a simple additive way. Saccharine facilitates the acquisition of drug-directed behavior. The slope of the acquisition trials for the morphine-saccharine group was significantly different from horizontal (O-slope) and significantly different from the slope found for the morphine without saccharine group.

Key words

d-Amphetamine Morphine Drug ingestion Saccharine 


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Copyright information

© Springer-Verlag 1976

Authors and Affiliations

  • Shirley Y. Hill
    • 1
  • Barbara J. Powell
    • 1
  1. 1.Department of PsychiatryWashington University School of MedicineSt. LouisU.S.A.

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