Psychopharmacology

, Volume 50, Issue 3, pp 281–283 | Cite as

Eine Apparatur zur Messung motorischer Funktionsstörungen bei Ratten

  • H. Ballhause
  • J. Kähling
Animal Studies

A device for the evaluation of motor incoordination in rats

Abstract

A runway apparatus for rats has been developed for measuring motor incoordination and running time. Animals were trained to run along an elevated narrow pathway. Frequency and severity of slipping off and running time were automatically counted.

Rats were given diazepam, phenobarbital or chlorpromazine orally and tested 1 h later. Diazepam, 8–64 mg/kg p.o., caused slipping off in a dose-dependent manner. Phenobarbital had a similar effect with 64 mg/kg p.o. Chloropromazine, 32 and 64 mg/kg p.o., caused other signs of motor deficit.

Key words

Motor incoordination Runway test Diazepam Phenobarbital Chlorpromazine Rat 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Coper, H., Lison, H.: Eine einfache Methode zur Feststellung von Nebenwirkungen zentralwirksamer Pharmaka auf motorische Funktionen bei Ratten. Pharmacopsychiatrie 1, 135–139 (1968)Google Scholar
  2. Gibbins, R. J., Kalant, H., LeBlanc, A. E.: A technique for accurate measurement of moderate degrees of alcohol intoxication in small animals. J. Pharmacol. exp. Ther. 159, 236–242 (1968)Google Scholar
  3. Kiesewetter, R., Müller, M.: Über die Beeinflussung des psychomotorischen Gedächtnisses der Ratte durch Benzilsäurediäthylaminoäthylester-hydrochlorid, 2-Methyl-2-n-propyl-propandiol-(1,3)-dicarbamat und Pervitin. Pharmazie 14, 84–91 (1959)Google Scholar
  4. Müller, M., Gebhard, J.: Zur Testung depressiv auf das Zentralnervensystem wirkender Pharmaka. Psychopharmacologia (Berl.) 1, 419–428 (1960)Google Scholar
  5. Rushton, R., Steinberg, H., Tinson, C.: Effects of a single experience on subsequent reactions to drugs. Brit. J. Pharmacol. 20, 99–105 (1963)Google Scholar

Copyright information

© Springer-Verlag 1976

Authors and Affiliations

  • H. Ballhause
    • 1
  • J. Kähling
    • 1
  1. 1.Biologische ForschungDr. K. Thomae GmbHBiberach an der RißBundesrepublik Deutschland

Personalised recommendations