, Volume 50, Issue 3, pp 269–274 | Cite as

The influence of hypothalamically administered reserpine on the sexual behavior of the female cat

  • Veronica A. Cerny
Animal Studies


Ovariectomized cats with intracerebral implants of reserpine, a monoamine depletor, were tested for sexual behavior by introducing them to sexually vigorous males and by artificial stimulation. Approximately a third of the animals mated in response to reserpine and another third exhibited some components of sexual behavior. The behavior exhibited by these animals had none of the frenzy of normal estrous behavior. Some components of the normal pattern were missing while all others were curtailed in duration and vigor. These animals responded with normal sexual behavior to intracerebrally and systemically administered estrogen. It is suggested that the unusual sexual behavior in response to reserpine was due to the release of these behavioral patterns from a monoamine system, inhibitory to sexual behavior.

Key words

Sexual behavior Reserpine Female cat 


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  1. Ahlenius, S., Engel, J., Erikson, H., Modigh, K., Sodersten, P.: Importance of central catecholamines in the mediation of lordosis behavior in ovariectomized rats treated with estrogen and inhibitors of monoamine synthesis. J. Neur. Trans. 33, 247–255 (1972)Google Scholar
  2. Beach, F. A.: Importance of progesterone to induction of sexual receptivity in spayed female rats. Proc. Soc. exp. Biol. (N.Y.) 51, 367–371 (1942)Google Scholar
  3. Boling, J. L., Blandau, R. J.: The estrogen-progesterone induction of mating response in the spayed female rat. Endocrinology 25, 259–264 (1939)Google Scholar
  4. Cerny, V. A.: The effect of systematically administered reserpine on the sexual behavior of the female cat. (In preparation)Google Scholar
  5. Davidson, J. M., Smith, E. R., Rogers, C. H., Bloch, G. J.: Relative thresholds of behavioral and somatic responses to estrogen. Physiol. Behav. 3, 227–229 (1968)Google Scholar
  6. Dewsbury, P. A.: Copulatory behavior of male rats following reserpine administration. Phychonom. Sci. 22, 177–179 (1971)Google Scholar
  7. Dewsbury, P. A., Dairs, H. N.: Effects of reserpine on copulatory behavior of male rats. Physiol. Behav. 5, 1331–1333 (1970)Google Scholar
  8. Donoso, A. O., Cukier, J.: Estrogen as a depressor of noradrenaline concentration in the anterior hypothalamus. Nature (Lond.) 218, 969–970 (1968)Google Scholar
  9. Donoso, A. O., Stefano, F. J. E.: Sex hormones and the concentration of noradrenaline and dopamine in the anterior hypothalamus of castrated rats. Experientia (Basel) 23, 665–666 (1965)Google Scholar
  10. Everitt, B. J., Fuxe, K., Hokfelt, T., Jonsson, G.: Studies on the role of monoamines in the hormonal regulation of sexual receptivity in the female rat. In: Serotonin—new vistas, Vol. 2, E. Costa, G. L. Gessa, and M. Sandler, eds., pp. 147–159, New York, Raven Press 1974Google Scholar
  11. Feldman, S., Conforti, N., Davidson, J. M.: Adrenocortical responses in rats with corticosteroid and reserpine implants. Neuroendocrinology 1, 228–239 (1966)Google Scholar
  12. Ferguson, J., Flenrikson, S., Cohen, H., Mitchell, G., Barchas, J., Dement, W.: Hypersexuality and behavior changes in cats caused by administration of p-chlorophenylalanine. Science 165, 499–501 (1970)Google Scholar
  13. Gawienowski, A. M., Merker, J. W., Damon, R. A.: Alteration of sexual behavior and sex accessory glands by p-chlorophenylalanine and testosterone. Life Sci. 12, 307–315 (1973)Google Scholar
  14. Gessa, G. L., Tagliamonte, A., Tagliamonte, P., Brodie, B. B.: Essential role of testosterone in the sexual stimulation induced by p-chlorophenylalanine in male animals. Nature (Lond.) 227, 616–617 (1970)Google Scholar
  15. Greulich, W. W.: Artificially induced ovulation in the cat (Felis domestica). Anat. Rec. 58, 217–224 (1934)Google Scholar
  16. Guyer, M. F.: Animal micrology. Chicago: University of Chicago Press 1953Google Scholar
  17. Harris, G. W., Michael, R. P.: The activation of sexual behavior by hypothalamic implants of oestrogen. J. Physiol. (Lond.) 171, 275–301 (1964)Google Scholar
  18. Hoyland, V. J., Shillito, E. E., Vogt, M.: The effect of parachlorophenylalanine on the behavior of cats. Brit. J. Pharmacol. 40, 659–667 (1970)Google Scholar
  19. Keller, H. H.: Depletion of cerebral monoamines by p-chlorophenylalanine in the cat. Experientia (Basel), 28, 177–178 (1972)Google Scholar
  20. Koella, W. P., Feldstein, A., Czioman, J. S.: The effect of parachlorophenylalanine on the sleep of cats. Electroenceph. clin. Neurophysiol. 25, 481–490 (1968)Google Scholar
  21. Lindström, L. H.: The effect of pilocarpine and oxotremorinne on oestrous behavior in female rats after treatment with monoamine depletors or monoamine synthesis inhibitors. Europ. J. Pharmacol. 15, 60–65 (1971)Google Scholar
  22. Van Maanen, J. H., Smelik, P. G.: Induction of pseudopregnancy in rats following local depletion of monoamines in the median eminence of the hypothalamus. Neuroendrocrinology 3, 177–186 (1968)Google Scholar
  23. McKinney, W. T., Eisig, R. G., Moran, E. C., Suomi, S. J., Harlow, H. F.: Effects of reserpine on the social behavior of rhesus monkeys. Dis. nerv. Syst. 32, 735–741 (1971)Google Scholar
  24. Meyerson, B. J.: Central nervous monoamines and hormone induced estrus behavior in the spayed rat. Acta physiol. scand. 63, Suppl, 241 (1964a)Google Scholar
  25. Meyerson, B. J.: Estrus behavior in spayed rats after estrogen or or progesterone treatment in combination with reserpine or tetrabenazine. Psychopharmacologia (Berl.) 6, 210–218 (1964b)Google Scholar
  26. Meyerson, B. J.: Amphetamine and 5-hydroxy-tryptamine inhibition of copulatory behavior in the female rat. Ann. Med. exp. Fenn. 46, 394–398 (1968)Google Scholar
  27. Meyerson, B. J., Lewander, T.: Serotonin synthesis inhibition and estrus behavior in female rates. Life Sci. 9, 661–671 (1970)Google Scholar
  28. Meyerson, B. J., Carrer, H., Eliasson, M.: 5-Hydroxytryptamine and sexual behavior in the female rat. In: Serotonin—new vistas, Vol. 2, E. Costa, G. L. Gessa, and M. Sandler, eds., pp. 229–242. New York: Raven Press 1974Google Scholar
  29. Michel, R. P.: Observations upon sexual behavior of the domestic cat (Felis catus L.) under laboratory conditions. Behavior 18, 1–24 (1961)Google Scholar
  30. Nickerson, L.: In: The pharmacological basis of therapeutics, L. S. Goodman and A. Gilman, eds., pp. 181, 571–572. New York: McMillan 1968Google Scholar
  31. Paris, C. A., Reski, J. A., Goy, R. W.: A possible mechanism for the induction of lordosis by reserpine in spayed rats. Biol. Reprod. 4, 23–30 (1971)Google Scholar
  32. Perachio, A. A., Marr, L.: The effect of p-chlorophenylalanine on primate sexual behavior cf. A. Zitrin, W. C. Dement, J. P. Barachas: Brain seratonin and male sexual behavior. In: Contemporary sexual behavior: Critical issues in the 1970's. J. Zubin and J. Money, eds., pp. 321–338. Baltimore: The John Hopkins University Press 1973Google Scholar
  33. Redmond, D. E., Jr., Mass, J. S., Kling, A., Graham, C. W., Dekirmenhian, H.: Social behavior of monkeys selectively depleted of monoamines. Science 174, 428–430 (1971)Google Scholar
  34. Salis, P., Dewsbury, D.: p-Chlorophenylalanine facilitates copulatory behavior in male rats. Nature (Lond.) 232, 400–401 (1971)Google Scholar
  35. Sawyer, C. H., Robinson, B. A.: Separate hypothalamic areas controlling pituitary gonadotropic function and mating behavior in female cats and rabbits. J. clin. Endocr. 16, 914–920 (1956)Google Scholar
  36. Scott, P. O.: The cat (Felis catus L.). In: UFAW handbook on the care and management of laboratory animals, pp. 505–567. Edinburgh-London: Livingstone 1967Google Scholar
  37. Scott, P. P., Lloyd-Jacob, M. A.: Some interesting features in the reproduction cycle of the cat. Stud. Fertil. 7, 123–129 (1955)Google Scholar
  38. Segal, D. A., Whalen, R. E.: Effect of chronic administration of p-chlorophenylalanine on sexual receptivity of the female rat. Psychopharmacologia (Berl.) 16, 434–438 (1970)Google Scholar
  39. Sheard, M.: The effect of p-chlorophenylalanine on behavior in rats; relation to brain serotonin and 5-hydroxyindolacetic acid. Brain Res. 15, 524–528 (1969)Google Scholar
  40. Shillito, E. E.: The effects of parachlorophenylalanine on social interaction of male rats. Brit. J. Pharmacol. 36, 193–194 (1967)Google Scholar
  41. Shillito, E. E.: Effects of parachlorophenylalanine on the behavior of castrated male rats. Brit. J. Pharmacol. 41, 404 (1971)Google Scholar
  42. Simpson, W. C., Dicara, L. V.: Estradiol inhibition of catecholamine elicited eating in the female rat. Pharmacol. Biochem. Behav. 1, 413–419 (1973)Google Scholar
  43. Sjöerdsma, A., Lovenberg, W., Engelman, K., Carpenter, W. T., Wyatt, R. J., Gessa, G. L.: Serotonin now: Clinical implications of inhibiting its synthesis with para-chlorophenylalanine. Ann. intern. Med. 73, 607–629 (1970)Google Scholar
  44. Smelik, P. G.: ACTH secretion after depletion of hypothalamic monoamines by reserpine implants. Neuroendocrinology 2, 247–254 (1967)Google Scholar
  45. Snider, R. S., Niemer, W. T.: A stereotaxic atlas of the cat brain. Chicago-London: University of Chicago Press 1961Google Scholar
  46. Stolk, J., Barchas, J., Dement, W., Schonberg, S.: Brain catecholamine metabolism following para-chlorophenylalanine (pCP) treatment. Pharmacologist 11, 258 (1969)Google Scholar
  47. Tagliamonte, A., Tagliamonte, P., Gessa, G. L., Brodie, B. B.: Compulsive sexual activity induced by p-chlorophenylalanine in normal and pinealectomized male rats. Science 166, 1433–1435 (1969)Google Scholar
  48. Tenen, S. S.: The effects of p-chlorophenylalanine a serotonin depletor on avoidance, acquisition, pain sensitivity and related behavior in the rat. Psychopharmacologia (Berl.) 10, 204–219 (1967)Google Scholar
  49. Windle, W. F., Cammermeyer, F.: Functional and structural observations on chronically reserpinized monkeys. Science 127, 1503–1504 (1958)Google Scholar
  50. Withrington, P., Zaimis, E.: The reserpine treated cat. Brit. J. Pharmacol. 17, 380–391 (1961)Google Scholar
  51. Zemlam, F. P., Ward, I. L., Crowley, W. R., Margules, P. L.: Actication of lordotic responding in female rats by suppression of serotonergic activity. Science 179, 1010–1011 (1973)Google Scholar
  52. Zitrin, A., Beach, F. A., Barchas, J. D., Dement, W. C.: Sexual behavior of male cats after administration of parachlorophenylalanine. Science 170, 868–870 (1970)Google Scholar

Copyright information

© Springer-Verlag 1976

Authors and Affiliations

  • Veronica A. Cerny
    • 1
  1. 1.Laboratories of Anatomy, Department of Animal Biology, School of Veterinary MedicineUniversity of PennsylvaniaPhiladelphiaU.S.A.

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