Psychopharmacology

, Volume 61, Issue 1, pp 81–83 | Cite as

Dietary modification of amphetamine stereotyped behaviour: The action of tryptophan, methionine, and lysine

  • Maxwell Taylor
Original Investigations

Abstract

Rats fed diets high in tryptophan, methionine, and tryptophan plus methionine or lysine were subsequently injected with 10 mg/kg d-amphetamine. The amount of amphetamine-induced stereotyped behaviour observed varied as a function of the dietary addition, with methionine showing the greatest difference to controls, and lysine the least. Whole brain catecholamine levels and 5-hydroxytryptamine levels also showed amino acid-specific changes.

Key words

Amphetamine Stereotyped behaviour Amino acids Biogenic amines 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Beckett, A. H., Brookes, L. G.: The effect of chain and ring substitution on the metabolism, distribution, and biological action of amphetamines. In: International symposium on amphetamines and related compounds, E. Costa and S. Garattini, eds., pp. 109–120. New York: Raven 1970Google Scholar
  2. Grahame-Smith, D. G.: Does the total turnover of brain 5-HT reflect the functional activity of 5-HT in the brain? In: Serotonin and behaviour, J. Barchas and E. Usdin, eds., pp. 5–7. New York: Academic Press 1973Google Scholar
  3. Holman, R. B., Angwin, P., Barchas, J. D.: Simultaneous determination of indole and catecholamines in small brain regions in the rat using a weak action exchange resin. Neuroscience 1, 147 (1976)Google Scholar
  4. Randrup, A., Munkvad, J.: Stereotyped activities produced by amphetamine in several animal species and man. Psychopharmacologia (Berl.) 11, 300 (1967)Google Scholar
  5. Shellenberger, M. K., Gordon, J. H.: A rapid, simplified procedure for simultaneous assay of norepinephrine, dopamine, and 5-hydroxytryptamine from discrete brain areas. Anat. Biochem. 39, 356 (1971)Google Scholar
  6. Singh, M. M., Kay, S. R.: Wheat gluten as a pathogenic factor in schizophrenia. Science 191, 401 (1976)Google Scholar
  7. Taylor, M.: Effects of L-tryptophan and L-methionine on activity in the rat. Br. J. Pharmacol. 58, 117 (1976a)Google Scholar
  8. Taylor, M.: Dietary constituents and amphetamine induced abnormal behaviour. Paper given at Second Annual Conference on ‘Gut absorption and antigens,’ Bangor (1976b)Google Scholar
  9. Taylor, M., Goudie, A. J., Mortimore, S., Wheeler, T. J.: Comparisons between behaviour elicited by high doses of amphetamine and fenfluramine; implications for the concept of stereotypy. Psychopharmacologia (Berl.) 40, 249 (1974)Google Scholar
  10. Wurtman, R. J., Fernstrom, J. D.: Effects of diet on brain neurotransmitters. Nutrition Rev. 32, 193 (1974)Google Scholar
  11. Wyatt, R. J., Erdelyi, E., Doamaral, J. R., Elliott, G. R., Renson, J., Barchas, J. D.: Tryptoline formation by a preparation from brain with 5-methyltetrahydrofolic acid and tryptamine. Science 187, 853 (1975)Google Scholar

Copyright information

© Springer-Verlag 1979

Authors and Affiliations

  • Maxwell Taylor
    • 1
    • 2
  1. 1.Department of PsychologyConcordia UniversityMontrealCanada
  2. 2.School of Psychology, Ulster CollegeThe Northern Ireland PolytechnicJordanstownUK

Personalised recommendations