Dietary modification of amphetamine stereotyped behaviour: The action of tryptophan, methionine, and lysine
- 21 Downloads
Rats fed diets high in tryptophan, methionine, and tryptophan plus methionine or lysine were subsequently injected with 10 mg/kg d-amphetamine. The amount of amphetamine-induced stereotyped behaviour observed varied as a function of the dietary addition, with methionine showing the greatest difference to controls, and lysine the least. Whole brain catecholamine levels and 5-hydroxytryptamine levels also showed amino acid-specific changes.
Key wordsAmphetamine Stereotyped behaviour Amino acids Biogenic amines
Unable to display preview. Download preview PDF.
- Beckett, A. H., Brookes, L. G.: The effect of chain and ring substitution on the metabolism, distribution, and biological action of amphetamines. In: International symposium on amphetamines and related compounds, E. Costa and S. Garattini, eds., pp. 109–120. New York: Raven 1970Google Scholar
- Grahame-Smith, D. G.: Does the total turnover of brain 5-HT reflect the functional activity of 5-HT in the brain? In: Serotonin and behaviour, J. Barchas and E. Usdin, eds., pp. 5–7. New York: Academic Press 1973Google Scholar
- Holman, R. B., Angwin, P., Barchas, J. D.: Simultaneous determination of indole and catecholamines in small brain regions in the rat using a weak action exchange resin. Neuroscience 1, 147 (1976)Google Scholar
- Randrup, A., Munkvad, J.: Stereotyped activities produced by amphetamine in several animal species and man. Psychopharmacologia (Berl.) 11, 300 (1967)Google Scholar
- Shellenberger, M. K., Gordon, J. H.: A rapid, simplified procedure for simultaneous assay of norepinephrine, dopamine, and 5-hydroxytryptamine from discrete brain areas. Anat. Biochem. 39, 356 (1971)Google Scholar
- Singh, M. M., Kay, S. R.: Wheat gluten as a pathogenic factor in schizophrenia. Science 191, 401 (1976)Google Scholar
- Taylor, M.: Effects of L-tryptophan and L-methionine on activity in the rat. Br. J. Pharmacol. 58, 117 (1976a)Google Scholar
- Taylor, M.: Dietary constituents and amphetamine induced abnormal behaviour. Paper given at Second Annual Conference on ‘Gut absorption and antigens,’ Bangor (1976b)Google Scholar
- Taylor, M., Goudie, A. J., Mortimore, S., Wheeler, T. J.: Comparisons between behaviour elicited by high doses of amphetamine and fenfluramine; implications for the concept of stereotypy. Psychopharmacologia (Berl.) 40, 249 (1974)Google Scholar
- Wurtman, R. J., Fernstrom, J. D.: Effects of diet on brain neurotransmitters. Nutrition Rev. 32, 193 (1974)Google Scholar
- Wyatt, R. J., Erdelyi, E., Doamaral, J. R., Elliott, G. R., Renson, J., Barchas, J. D.: Tryptoline formation by a preparation from brain with 5-methyltetrahydrofolic acid and tryptamine. Science 187, 853 (1975)Google Scholar