, Volume 58, Issue 1, pp 99–104 | Cite as

Antipunishment effects of diazepam: Interaction with shock and food deprivation levels in pigs

  • Robert Dantzer
Original Investigations


The effects of 1 mg/kg diazepam on punished behaviour of pigs were inyestigated under various degrees, of food deprivation and/or shock level. Responses emitted during the punishment signal were affected more by the shock level than by the degree of food deprivation while nonpunished responses rates were modified by neither factor. Diazepam treatment increased the number of responses emitted during the punishment signal but interacted with the shock intensity: drug effects were attenuated when the shock intensity was severe, in spite of an equivalent control baseline. Diazepam also increased the overall rate of nonpunished responding. The drug treatment had no reliable effect on flinch and escape thresholds measured in separate experiments. The effects of diazepam on punished responding do not appear to be related to eventual changes in food motivation or sensitivity to electric shock

Key words

Pig Diazepam Punished responding Food deprivation level Shock intensity Sensitivity to electric shock 


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  1. Azrin, N. H., Holz, W. C.: Punishment. In: Operant behavior, W. K. Honig, ed., pp. 380–447. New York: Appleton-Century-Crofts 1966Google Scholar
  2. Bignami, G.: Behavioral pharmacology and toxicology. Annu. Rev. Pharmacol. Toxicol. 16, 329–366 (1976)Google Scholar
  3. Cook, L., Davidson, A. B.: Effects of behaviorally active drugs in a conflict-punishment procedure in rats. In: The benzodiazepines, S. Garattini, E. Mussini, and L. O. Randall, eds., pp. 327–345. New York: Raven 1973Google Scholar
  4. Cook, L., Sepinwall, J.: Behavioral analysis of the effects and mechanism of action of benzodiazepines. Adv. Biochem. Psychopharmacol. 14, 1–28 (1975)Google Scholar
  5. Dantzer, R.: Etude de l'activité des substances psychotropes sur le comportement de punition du Porc. J. Pharmacol. 6, 323–340 (1975)Google Scholar
  6. Dantzer, R.: Effect of diazepam on performance of pigs in a progressive ratio schedule. Physiol. Behav. 17, 161–163 (1976)Google Scholar
  7. Dantzer, R.: Behavioral effects of benzodiazepines. A review. Biobehav. Rev. 1, 71–86 (1977)Google Scholar
  8. Dantzer, R., Roca, M.: Tranquilizing effects of diazepam in pigs subjected to a punishment procedure. Psychopharmacologia (Berl.) 40, 235–240 (1974)Google Scholar
  9. Frontali, M., Amorico, L., De Acetis, L., Bignami, G.: A pharmacological analysis of processes underlying differential responding: a review and further experiments with scopolamine, amphetamine, lysergic acid diethylamide (LSD-25), chlordiazepoxide, physostigmine, and chlorpromazine. Behav. Biol. 18, 1–74 (1976)Google Scholar
  10. Geller, I., Kulak, J. T., Jr., Seifter, J.: The effects of chlordiazepoxide and chlorpromazine on a punishment discrimination. Psychopharmacologia (Berl.) 3, 374–385 (1962)Google Scholar
  11. Hole, K., Marsden, C. A.: Unchanged sensitivity to electric shock in 1-tryptophan treated rats. Pharmacol. Biochem. Behav. 3, 307–309 (1975)Google Scholar
  12. Houser, V. P.: The alteration of aversive thresholds after chronic administration of two tranquilizing agents. Behav. Biol. 12, 383–392 (1975)Google Scholar
  13. Houser, V. P., Paré, W. P.: Analgesic potency of sodium salicylate, indomethacin and chlordiazepoxide as measured by the spatial preference technique in the rat. Psychopharmacologia (Berl.) 32, 121–131 (1973)Google Scholar
  14. Kelleher, R. T., Morse, W. H.: Determinants of the specificity of behavioral effects of drugs. Ergeb. Physiol. 60, 1–56 (1968)Google Scholar
  15. Margules, D. L., Stein, L.: Neuroleptics vs. tranquilizers: evidence from animal behavior of mode and site of action. Excerpta Medica Int. Congress Series 129, 108–120 (1967)Google Scholar
  16. McMillan, D. E.: Drugs and punished responding. III. Punishment intensity as a determinant of drug effect. Psychopharmacologia (Berl.) 30, 61–74 (1973)Google Scholar
  17. McMillan, D. E.: Determinants of drug effects on punished responding. Fed. Proc. 34, 1870–1879 (1975)Google Scholar
  18. McMillan, D. E.: Drugs and punished responding. VI. Bodyweight as a determinant of drug effects. Res. Commun. Chem. Path. Pharmacol. 13, 1–8 (1976)Google Scholar
  19. Randall, L. O., Schallek, W., Sternbach, L. H., Ning, R. Y.: Chemistry and pharmacology of 1,4-benzodiazepines. In: Psychopharmacological agent, M. Gordon, ed., vol. 3, pp. 175–281. New York: Academic 1974Google Scholar
  20. Soubrié, P., Kulkarni, S., Simon, P., Boissier, J. R.: Effets des anxiolytiques sur la prise de nourriture de rats et de souris placés en situation nouvelle ou familière. Psychopharmacologia (Berl.) 45, 203–210 (1975)Google Scholar
  21. Ts'o, T. O. T., Chenoweth, M. B.: Comparison between chronic chlordiazepoxide treatment and shock removal in a conflict situation in rats. Neuropharmacology 15, 99–101 (1976)Google Scholar
  22. Wedeking, P. W.: Comparison of chlordiazepoxide and food deprivation in rats on fixed ratio satiation schedule. Physiol. Behav. 10, 707–710 (1973)Google Scholar
  23. Wise, R. A., Dawson, V.: Diazepam-induced eating and leverpressing for food in sated rats. J. Comp. Physiol. Psychol. 86, 930–941 (1974)Google Scholar

Copyright information

© Springer-Verlag 1978

Authors and Affiliations

  • Robert Dantzer
    • 1
  1. 1.Station de Pharmacologie-ToxicologieI. N. R. A.ToulouseFrance

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