Abstract
Methylphenidate induces psychostimulation and increases cardiovascular parameters, and its psychostimulant effects have been proposed to occur via a dopaminergic mechanism. The effect of methylphenidate on serum prolactin was utilized as a method of evaluating methylphenidate's central dopaminergic effects. Methylphenidate was not found to exhibit a consistent effect on serum prolactin. Thus, its effect on serum prolactin does not parallel its behavioral activating properties, suggesting that such activation may not involve dopamine. Possibly, norepinephrine or other noncatecholaminergic neurotransmitters are involved in methylphenidate-induced behavioral activation.
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Clemens, J. A., Smalstig, E. B., Sanyo, B. P.: Antipsychotic drugs stimulate prolactin release. Psychopharmacologia (Berl.) 40, 123–127 (1975)
Ferris, R., Tang, F., Maxwell, R.: A comparison of the capacities of isomers of amphetamine, deoxypiradrol and methylphenidate to inhibit the uptake of tritiated catecholamines into rat cerebral cortex slices, synaptosomal preparations of rat nerves and rabbit aorta. J. Pharmacol. Exp. Ther. 181, 407–416 (1972)
Frantz, A. G., Suh, H. K.: L-Dopa and the control of prolactin secretion. Advances in neurology 5, pp. 456–477. New York: Raven Press 1974
Frantz, A. G.: The regulation of prolactin secretion in humans. In: Frontiers in neuroendocrinology, W. F. Ganong and L. Martini, eds., pp. 337–374. New York: Raven Press 1973
Harris, J., Baldessarini, R.: Uptake of [3H]-catecholamines by homogenates of rat corpus striatum and cerebral cortex: effects of amphetamine analogues. Neuropharmacology 12, 669–679 (1973)
Huey, L., Janowsky, D. S., Judd, L. L., Abrams, A., parker, D.: Effects of lithium on methylphenidate psychostimulation. Am. Psychiatr. Assoc., New Research Abstracts, p. 3, May, 1977
Janowsky, D. S., Davis, J. M.: Methylphenidate, dextroamphetamine, and levamphetamine: effects on schizophrenic symptoms. Arch. Gen. Psychiatry 33, 304–308 (1976)
Janowsky, D. S., El-Yousef, M. K., Davis, J. M., Sekerke, J.: Provocation of schizophrenic symptoms by intravenous administration of methylphenidate. Arch. Gen. Psychiatry 28, 185–191 (1973)
Janowsky, D. S., Huey, L., Storms, L., Judd, L. L.: Methylphenidate effects on psychologic tests in acute schizophrenics. Arch. Gen. Psychiatry 34, 189–194 (1977)
Lal, S., DeLaVega, C. E., Sourkes, T. L., Friesen, H. G.: Effect of apomorphine on growth hormone, prolactin, luteinizing hormone and follicle-stimulating hormone levels in human serum. J. Clin. Endocrinol. Metab. 37, 719–724 (1973)
Lu, K. H., Meites, J.: Inhibition by L-dopa and monoamine oxidase inhibitors of pituitary prolactin release: stimulation by methyldopa and d-amphetamine. Proc. Soc. Exp. Biol. 137, 480–483 (1971)
Martin, J. B., Smarthji, L., Tolis, G.: Inhibition by apomorphine of prolactin secretion in patients with elevated serum prolactin. J. Clin. Endocrinol. Metab. 39, 180–182 (1974)
Meltzer, H. Y., Fang, V. S.: The effect of neuroleptics on serum prolactin in schizophrenic patients. Arch. Gen. Psychiatry 33, 279–286 (1976)
Meltzer H. Y., Sachar, D. J., Frantz, A. G.: Serum prolactin levels in unmedicated schizophrenic patients. Arch. Gen. Psychiatry 31, 564–569 (1974)
Parker, D. C., Rossman, L. G., Vanderlaan, E. F.: Sleep-related nyctohumeral and briefly episodic variation in human plasma prolactin concentrations. J. Clin. Endocrinol. Metab. 36, 119–124 (1973)
Rubin, R. T., Poland, R. E., O'Connor, D.: Selective neuroendocrine effects of low dose haloperidol in normal adult men. Psychopharmacology 47, 135–140 (1976)
Sachar, E. J., Frantz, A. G., Altman, N.: Growth hormone and prolactin in unipolar and bipolar depressed patients: responses to hypoglycemia and L-dopa. Am. J. Psychiatry 160, 1362–1367 (1973)
Sachar, E. J., Gruen, P. H., Altman, N., Halpern, F. S., Frantz, A. G.: Use of endocrine techniques in psychopharmacologic research. In: Hormones, behavior and psychopathology, E. J. Sachar, ed., pp. 161–175. New York: Raven Press 1976
Sachar, E. J., Gruen, P. H., Karasu, T. B., Altman, N., Frantz, A. G.: Thioridazine stimulates prolactin secretion in man. Arch. Gen. Psychiatry 32, 885–886 (1975)
Schell-Krüger, J.: Comparative studies of various amphetamine analogues demonstrating different interactions with the metabolism of the catecholamines in the brain. Eur. J. Pharmacol 14, 47–59 (1971)
Smalstig, E. B., Sawyer, B. D., Clemens, J. A.: Inhibition of prolactin release by apomorphine. Endocrinology 95, 123–129 (1974)
Thornburg, J., Moore, K.: Dopamine and norepinephrine uptake by rat brain synaptosomes: relative inhibitory potencies of l- and d-amphetamine and amantadine. Res. Commun. Chem. Pathol. Pharmacol. 5, 81–89 (1973)
van Kammen, D. P., Siris, S. G., Docherty, J. P., Bunney, W. E.: Effects of amphetamine on prolactin in schizophrenia. Am. Psychiatr. Assoc., New Research Abstracts, No.3, Annual Meeting, May, 1977
Wilson, R. G., Hamilton, J. R.: The effect of long-term phenothiazine therapy on plasma prolactin. Br. J. Psychiatry 127, 71–74 (1975)
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Janowsky, D.S., Leichner, P., Parker, D. et al. Methylphenidate and serum prolactin in man. Psychopharmacology 58, 43–47 (1978). https://doi.org/10.1007/BF00426788
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DOI: https://doi.org/10.1007/BF00426788