, Volume 54, Issue 2, pp 149–152 | Cite as

Effects of cyclic analogs of GABA on protein synthesis and discrimination learning

  • Dalila Martínez de Muñoz
  • Alejandro Oscos


Three cyclic analogs of γ-aminobutyric acid (GABA)-5-ethyl, 5-phenyl, 2-pyrrolidinone (EPP), 5-diphenyl, 2-pyrrolidinone (DPP), and 5-methyl, 5-phenyl, 2-pyrrolidinone (MPP)-were studied in relation to protein synthesis and the latter in relation to discrimination learning. The present study shows that when different groups of rats were injected subcutaneously with 10 mg/kg of EPP or DPP, the protein synthesis in vitro was inhibited 75% in brain mitochondria. MPP at the same doses was the less potent inhibitor of mitochondria protein synthesis. Experiments on discrimination learning show that 10 mg/kg of MPP enhance the response decision speed in presence of S+ (white arm) and S- (black arm).

Key words

GABA-anticonvulsants Protein synthesis Discrimination learning 


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Copyright information

© Springer-Verlag 1977

Authors and Affiliations

  • Dalila Martínez de Muñoz
    • 1
  • Alejandro Oscos
    • 1
  1. 1.Departamento de NeurocienciasCentro de Investigación y de Estudios Avanzados del Instituto Politécnico NacionalMexico 14México

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