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Tardive dyskinesia: A clinical test of the supersensitivity hypothesis

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Abstract

Patients with tardive dyskinesia showed no significant difference in CSF HVA when compared with groups of schizophrenic or depressives. CSF cAMP in the tardive dyskinesia group was significantly lower when compared to schizophrenics but not depressives. These results do not support a dopamine-receptor supersensitivity hypothesis in permanent tardive dyskinesia.

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Authors and Affiliations

  1. Department of Psychiatry, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut, USA

    Malcolm B. Bowers Jr. & Daniel Moore

  2. Department of Neurology, Boston VA Hospital and Boston University School of Medicine, Boston, USA

    Daniel Tarsy

  3. Division of Neurology, Department of Medicine, New England Deaconess Hospital and Harvard Medical School, Boston, USA

    Daniel Tarsy

Authors
  1. Malcolm B. Bowers Jr.
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  2. Daniel Moore
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  3. Daniel Tarsy
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Bowers, M.B., Moore, D. & Tarsy, D. Tardive dyskinesia: A clinical test of the supersensitivity hypothesis. Psychopharmacology 61, 137–141 (1979). https://doi.org/10.1007/BF00426727

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  • DOI: https://doi.org/10.1007/BF00426727

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