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Psychopharmacology

, Volume 53, Issue 1, pp 55–63 | Cite as

Evidence for increased apomorphine-sensitive dopaminergic effects after acute treatment with morphine

  • J. Scheel-Krüger
  • K. Golembiowska
  • E. Mogilnicka
Animal Studies Original Investigations

Abstract

Apomorphine in a very small non-stimulant dose 0.05 mg/kg s.c. antagonized the locomotor stimulant effect of morphine (50 mg/kg) in mice. Apomorphine (0.05 mg/kg) antagonized also the locomotor stimulant effect of a single low dose of morphine (2 mg/kg) in the rat as well as “the late stimulatory effect” seen after a higher dose of morphine (10 or 20 mg/kg). The pretreatment with morphine in increasing doses induced an increasing degree of potentiation of stereotyped behavior induced by high doses of apomorphine (0.5 and 2 mg/kg s.c.) in the rat. The apomorphine stereotyped biting/gnawing activity was found strongly increased by morphine (10–50 mg/kg) during the time interval where morphine given alone induced catalepsy. Our results indicate that the acute treatment with morphine may induce an increase of apomorphine sensitive dopaminergic mechanisms. The inhibitory effect by a very small dose of apomorphine (0.05 mg/kg) of morphine stimulation may be due to a presynaptic dopamine receptor stimulant effect of apomorphine. The antagonism by the serotonin antagonist methergoline of morphine catalepsy and the increase by this drug of “the late morphine excitation” indicate in addition a role of a serotonergic mechanism.

Key words

Apomorphine Morphine Behavioral effects Dopaminergic mechanisms Serotonin Mice Rats 

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Copyright information

© Springer-Verlag 1977

Authors and Affiliations

  • J. Scheel-Krüger
    • 1
  • K. Golembiowska
    • 2
  • E. Mogilnicka
    • 2
  1. 1.Psychopharmacological Research Laboratory, Dept. E.Sct. Hans HospitalRoskildeDenmark
  2. 2.Dept. of PharmacologyPolish Academy of Science (PAN)KrakowPoland

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