Skip to main content
Log in

Lithium therapy and erythrocyte membrane cation carrier

  • Short Reports
  • Human Pharmacology
  • Published:
Psychopharmacologia Aims and scope Submit manuscript

Abstract

Plasma cortisol and erythrocyte Na-K ATPase, ouabain sensitive K+ influx, lithium, sodium and potassium concentrations were measured twice when patients were on placebo and twice when they were on lithium therapy. The erythrocyte Na-K ATPase was significantly higher during the lithium than during the placebo treated period, whereas the other biochemical values measured showed no significant difference between the two phases.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Beaugé, L. A., Ortiz, O.: Further evidence for a potassium like action of lithium ions on sodium efflux in frog skeletal muscle. J. Physiol. (Paris) 226, 675–697 (1972)

    Google Scholar 

  • Cade, J. P. J.: Lithium salts in the treatment of psychotic excitement. Med. J Aust. 2, 349–352 (1949)

    Google Scholar 

  • Carroll, B. J., Steven, L., Pope, R. A., Davies, B.: Sodium transfer from plasma to CSF in severe depressive illness. Arch. gen. Psychiat. 21, 77–81 (1969)

    Google Scholar 

  • Coppen, A.: Abnormality of the blood-cerebrospinal-fluid barrier of patients suffering from a depressive illness. J. Neurol. Neurosurg. Psychiat. 23, 156–161 (1960)

    Google Scholar 

  • Cundall, R. L., Brooks, P. W., Murray, L. G.: A controlled evaluation of lithium prophylaxis in affective disorders. Psychol. Med. 2, 308–311 (1972)

    Google Scholar 

  • Dick, D. A. T., Dick, E. G., Le Poidevin, D., Naylor, G. J.: Sodium and potassium transport in depressive illness. J. Phsyiol. (Paris) 227, 30–32 P (1972)

    Google Scholar 

  • Fotherby, K., Ashcroft, G. W., Affleck, J. W., Forrest, A. D.: Studies on sodium transfer and 5 hydroxyindoles in depressive illness. J. Neurol. Neurosurg. Psychiat. 26, 71–73 (1963)

    Google Scholar 

  • Glen, A. I. M., Bradbury, M. N. B., Wilson, J.: Stimulation of the sodium pump in the red blood cell by lithium and potassium. Nature (Lond.) 239, 399–401 (1972)

    Google Scholar 

  • Glen, A. I. M., Ongley, G. C., Robinson, K.: Diminished membrane transport in manic-depressive psychosis and recurrent depression. Lancet 1968 II, 241–243

    Google Scholar 

  • Hartigan, G. P.: The use of lithium salts in affective disorders. Brit. J. Psychiat. 109, 810–814 (1963)

    Google Scholar 

  • Maggs, R.: Treatment of manic illness with lithium carbonate. Brit. J. Psychiat. 109, 55–65 (1963)

    Google Scholar 

  • Mattingly, D.: A simple fluorimetric method for the estimation of free 11-hydroxycorticoids in human plasma. J. clin. Path. 15, 374–379 (1962)

    Google Scholar 

  • Mendels, J., Secunda, S. K., Dyson, W. L.: A controlled study of the antidepressant effects of lithium carbonate. Arch. gen. Psychiat. 26, 154–157 (1972)

    Google Scholar 

  • Naylor, G. J., Dick, D. A. T., Dick, E. G., Le Poidevin, D., Whyte, S. F.: Erythrocyte membrane cation carrier in depressive illness. Psychol. Med. 3, 502–508 (1973)

    Google Scholar 

  • Naylor, G. J., Donald, J. M., Le Poidevin, D., Reid, A. H.: A double blind trial of long term lithium therapy in mental defectives. Brit. J. Psychiat. 124, 52–57 (1974)

    Google Scholar 

  • Pybus, J., Bowers, G. N.: Estimate of lithium in plasma using atomic absorption spectrophotometry. Clin. Chem. 16, 139–143 (1970)

    Google Scholar 

  • Rask-Madsen, J., Baastrup, P. C., Schwartz, M.: Lithium induced hyperpolarization of the human rectum in vivo. Brit. med. J. 1972 II, 496–498

    Google Scholar 

  • Schou, M.: Normothymics. Brit. J. Psychiat. 109, 803–809 (1963)

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Naylor, G.J., Dick, D.A.T., Dick, E.G. et al. Lithium therapy and erythrocyte membrane cation carrier. Psychopharmacologia 37, 81–86 (1974). https://doi.org/10.1007/BF00426685

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00426685

Key words

Navigation