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MAO inhibition and the effects of centrally administered LSD, serotonin, and 5-methoxytryptamine on the conditioned avoidance response in rats

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Abstract

Pretreatment with the MAO-inhibitors iproniazid, clorgyline, or deprenyl abolishes the effects of LSD on the conditioned avoidance response (CAR) in rats. The effects of serotonin (5-HT) and 5-methoxytryptamine (5-MT) are greatly potentiated by these substances. Brain levels of LSD are not affected by MAO inhibition whereas levels of 5-HT and 5-MT are significantly elevated. It is postulated that the decreased behavioral response to LSD is the result of ‘MAO inhibitor-induced’ changes whereas the increased response of 5-HT and 5-MT results from increased brain levels of these compounds.

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Authors and Affiliations

  1. Department of Pharmacology, Thomas Jefferson University, 1020 Locust Street, 19107, Philadelphia, PA, USA

    Walter C. Prozialeck & Wolfgang H. Vogel

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  1. Walter C. Prozialeck
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  2. Wolfgang H. Vogel
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Prozialeck, W.C., Vogel, W.H. MAO inhibition and the effects of centrally administered LSD, serotonin, and 5-methoxytryptamine on the conditioned avoidance response in rats. Psychopharmacology 60, 309–310 (1979). https://doi.org/10.1007/BF00426673

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  • DOI: https://doi.org/10.1007/BF00426673

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