Abstract
The effect of a series of neuroleptic drugs on the drinking response elicited by intracerebroventricular injection of either angiotensin or carbachol into conscious rats was studied. The i. p. injection of haloperidol, cis-flupenthixol, or fluphenazine antagonized both angiotensin-induced and carbachol-induced drinking. When injected into the lateral ventricles, the neuroleptics haloperidol, fluphenazine, cis-flupenthixol and sulpiride were potent inhibitors of angiotensin-induced drinking, but had little effect on the dipsogenic action of carbachol. Clozapine, administered centrally, antagonized drinking caused by both angiotensin and carbachol. Pimozide and chlorpromazine were also potent inhibitors of angiotensin-induced drinking, while trans-flupenthixol was inactive. Our results support the concept of an involvement of dopamine in angiotensin-induced drinking.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Booth, D. A.: Mechanism of action of norepinephrine in eliciting an eating response on injection into the rat hypothalamus. J. Pharmacol. Exp. Ther. 160, 336–348 (1968)
Costall, B., Naylor, R. J.: Antagonism of the hyperactivity induced by dopamine applied intracerebrally to the Nucleus Accumbens septi by typical neuroleptics and by clozapine, sulpiride and thioridazine. Eur. J. Pharmacol. 35, 161–168 (1976)
Elliot, P. N. C., Jenner, P., Huizing, G., Marsden, C. D., Miller, R.: Substitued benzamides as cerebral dopamine antagonists in rodents. Neuropharmacology 16, 333–342 (1977)
Epstein, A. N., Fitzsimons, J. T., Johnson, A. K.: Peptide antagonists of the Renin Angiotensin system and the elucidation of receptors for angiotensin induced drinking. J. Physiol. (Lond.) 238, 34P-35P (1974)
Epstein, A. N., Fitzsimons, J. T., Rolls, B. J.: Drinking induced by injection of angiotensin into the brain of the rat. J. Physiol. (Lond.) 210, 457–474 (1970)
Fitzsimons, J. T.: Thirst. Physiol. Rev. 52, 468–561 (1972)
Fitzsimons, J. T., Setler, P. E.: The relative importance of central nervous catecholaminergic and cholinergic mechanisms in drinking in response to angiotensin and other thirst stimuli. J Physiol. (Lond.) 250, 613–631 (1975)
Haase, H. J., Floru, L., Ulrich, F. Clinical neuroleptic investigation of N [1-ethyl-pyrrolidine-2-yl-methyl]-2-Methoxy-5-Sulfamoylbenzamide, the neuroleptic Sulpiride (Dogmatil) using acute schizophrenics. Int. Pharmacopsychiatry 9, 77 (1974)
Honda, F., Satoh, Y., Shimomura, K., Satoh, H., Noguchi, H., Uchida, S., Kato, R.: Dopamine receptor blocking activity of Sulpiride in the central nervous system. J. Pharmacol. 27, 397–411 (1977)
Iversen, L. L.: Dopamine receptors in the brain. Science 188, 1084–1089 (1975)
Kebabian, J. W.: Biochemical regulation and physiological significance of cyclic nucleotides in the nervous system. In: Advances in cyclic nucleotides research, vol. 8, P. Greengard G. A. Robison, eds., pp. 421–507. New York: Raven Press 1977
König, J. F. R., Klippel, R. A.: The rat brain: A stereotaxic atlas of the forebrain and lower parts of the brain stem. Baltimore: Williams and Wilkins 1963
Laville, C., Margarit, J.: Activité antiémétique du Sulpiride vis-à-vis des divers poisons émetisants chez le chien. Comp. Rend. Soc. Biol. (Paris) 162, 869 (1968)
Miller, R. J., Hiley, C. R.: Antimuscarinic properties of neuroleptics and drug induced Parkinsonism. Nature 248, 596–597 (1974)
Moller-Nielsen, I., Petersen, V., Nymark, M., Franck, K. F., Boeck, V., Fjalland, B., Christensen, A. V.: The comparative pharmacology of flupenthixol and some reference neuroleptics. Acta Pharmacol. Toxicol. (Kbh) 33, 353–362 (1973)
Seeman, P., Staiman, A., Chau-Wong, M.: The nerve impulse blocking actions of tranquillisers and the binding of neuroleptics to synaptosome membranes. J. Pharmacol. Exp. Ther. 190, 123–130 (1974)
Seeman, P., Lee, T.: Antipsychotic drugs: Direct correlation between clinical potency and presynaptic action on dopamine neurones. Science 188, 1217–1219 (1975)
Severs, W. B., Summy-Long, J., Taylor, J. S., Conner, J. S.: A central effect of angiotensin: Release of pituitary pressor material. J. Pharmacol. Exp. Ther. 174, 27–34 (1970)
Stille, G., Lauener, M., Eichenberger, E.: The pharmacology of 8-chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo (b, e) (1,4) diazepine (clozapine). Farmaco. (Prat) 26, 603–625 (1971)
Trabucchi, M., Longoni, R., Fresia, P., Spano, P. F.: Sulpiride: a study of the effects on dopamine receptors in rat neostriatum and limbic forebrain. Life Sci 17, 1151–1156 (1975)
Ungerstedt, U.: Adipsia and aphagia after 6-hydroxydopamine induced degeneration of the nigro-striatal dopamine system. Acta Physiol. Scand. [Suppl.] 367, 95–122 (1971)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Sumners, C., Woodruff, G.N., Poat, J.A. et al. The effect of neuroleptic drugs on drinking induced by central administration of angiotensin or carbachol. Psychopharmacology 60, 291–294 (1979). https://doi.org/10.1007/BF00426670
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00426670