Abstract
In an attempt to define the nature of the involvement of Δ9-tetrahydrocannabinol (THC) with central cholinergic neurotransmission, the effects of THC on direct cholinergic stimulation of the rat brain were investigated. THC, in doses of 3 mg/kg and 6 mg/kg, administered intraperitoneally (i.p.), potentiated the effects of carbachol injection into the lateral septal nucleus, as manifested by enhancement of the drinking response elicited by the septal carbachol injection and by potentiation of the tendency of this carbachol injection to induce abnormal motor responses. Although atropine (10 mg/kg, i.p.) completely blocked the carbachol induced drinking, the atropine did not completely block the drinking response when THC was given with carbachol. The results indicate an apparent sensitization, by THC, of a limbic cholinergic system.
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References
Abel, E.: Marijuana and memory. Nature 227, 1151–1152 (1970)
Brown, J.: Some anticholinergic-like behavioral effects of trans(-) Δ9-Tetrahydrocannabinol tetrahydrocannabinol. Psychopharmacologia 21, 294–301 (1971)
Drew, W. G., Miller, L. L.: Cannabis: Neural mechanisms and behavior — a theoretical review. Pharmacology 11, 12–32 (1974)
Elsmore, T. F., Fletcher, G. V.: Δ9-Tetrahydrocannabinol: Aversive effects in rat at high doses. Science 175, 911–912 (1972)
Fisher, A. E., Coury, J. N.: Cholinergic tracing of a central neural circuit underlying the thirst drive. Science 138, 691–693 (1962)
Friedman, E., Hanin, I., Gershon, S.: Effect of tetrahydrocannabinols on 3H-acetylcholine biosynthesis in various rat brain slices. J. Pharmacol. Exp. Ther. 196, 339–345 (1976)
Goldman, H., Dagirmanjian, R., Drew, W. G., Murphy, S.: Δ9-Tetrahydrocannabinol alters flow of blood to subcortical areas of the conscious rat brain. Life Sci. 17, 477–482 (1975)
Grisham, M. G., Ferraro, D. P.: Biphasic effects of Δ9-tetrahydrocannabinol on variable interval schedule performance in rats. Psychopharmacologia 27, 163–169 (1972)
Grossman, S. P.: Effects of adrenergic or cholinergic stimulation on hypothalamic mechanisms. Am. J. Physiol. 202, 1230–1236 (1962)
Levitt, R. A., Boley, R. P.: Drinking elicited by injection of eserine or carbachol into the rat brain. Physiol. Behav. 5, 693–695 (1970)
Levitt, R. A., Fisher, A. E.: Anticholinergic blockade of centrally induced thirst. Science 154, 520–522 (1966)
Newburgh, L. H., Leaf, A.: Significance of Body Fluids in Clinical Medicine, 2nd. ed. Springfield: Thomas 1955
Pellegrino, L. J., Cushman, A. J.: A stereotaxic atlas of the rat brain. New York: Meredith 1967
Singer, G., Montgomery, R. B.: Functional relationships of brain circuits in control of drinking behavior. Life Sci 9, Part 1, 91–97 (1970)
Stein, L., Seifter, J.: Muscarinic synapses in the hypothalamus. Am. J. Physiol. 202, 751–756 (1962)
Tart, C. T.: Marijuana intoxication: Common experiences. Nature 226, 701–704 (1970)
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Duncan, G.E., Dagirmanjian, R. Δ9-Tetrahydrocannabinol Sensitization of the rat brain to direct cholinergic stimulation. Psychopharmacology 60, 237–240 (1979). https://doi.org/10.1007/BF00426661
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DOI: https://doi.org/10.1007/BF00426661