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Psychopharmacology

, Volume 68, Issue 1, pp 105–107 | Cite as

Effect of intraperitoneally administered GABA on haloperidol-induced catalepsy in the rat

  • J. J. Balsara
  • J. H. Jadhav
  • A. G. Chandorkar
Short Report

Abstract

Pretreatment with GABA (250–1,000 mg/kg, IP) potentiated the cataleptogenic effect of haloperidol in a dose-dependent manner in rats. GABA (GABA, B.D.H. Ltd.) alone in a dose of 2,000 mg/kg (IP) also induced catalepsy. The results may be due to partial access of blood-borne GABA to the CNS, leading to inhibition of nigro-striatal dopaminergic neurons involved in the functioning of the corpus striatum.

Key words

GABA Haloperidol Catalepsy 

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Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • J. J. Balsara
    • 1
  • J. H. Jadhav
    • 1
  • A. G. Chandorkar
    • 1
  1. 1.Department of PharmacologyV. M. Medical CollegeSolapurIndia

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