, Volume 68, Issue 1, pp 105–107 | Cite as

Effect of intraperitoneally administered GABA on haloperidol-induced catalepsy in the rat

  • J. J. Balsara
  • J. H. Jadhav
  • A. G. Chandorkar
Short Report


Pretreatment with GABA (250–1,000 mg/kg, IP) potentiated the cataleptogenic effect of haloperidol in a dose-dependent manner in rats. GABA (GABA, B.D.H. Ltd.) alone in a dose of 2,000 mg/kg (IP) also induced catalepsy. The results may be due to partial access of blood-borne GABA to the CNS, leading to inhibition of nigro-striatal dopaminergic neurons involved in the functioning of the corpus striatum.

Key words

GABA Haloperidol Catalepsy 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Andén, N.-E., Butcher, S. G., Corrodi, H., Fuxe, K., Ungerstedt, U.: Receptor activity and turnover of dopamine and noradrenaline after neuroleptics. Eur. J. Pharmacol. 11, 303–314 (1970)Google Scholar
  2. Andén, N.-E., Stock, G.: Inhibitory effect of gammahydroxybutyric acid and gammaaminobutyric acid on the dopamine cells in the substantia nigra. Naunyn Schmiedebergs Arch. Pharmacol. 279, 89–92 (1973)Google Scholar
  3. Bartholini, G., Stadler, H.: Cholinergic and GABA-ergic influences on the dopamine turnover in extrapyramidal system. In: Chemical tools in catecholamine research, vol. II. Regulation of catecholamine turnover, O. Almgren, A. Carlsson, and J. Engel, eds., pp. 235–241. Amsterdam: North Holland 1975Google Scholar
  4. Biswas, B., Carlsson, A.: The effect of intraperitoneally administered GABA on brain monoamine metabolism. Naunyn Schmiedebergs Arch. Pharmacol. 299, 47–51 (1977)Google Scholar
  5. Biswas, B., Carlsson, A.: Effect of intraperitoneally administered GABA on the locomotor activity of mice. Psychopharmacology 59, 91–94 (1978)Google Scholar
  6. Carlsson, A., Lindqvist, M.: Effect of chlorpromazine or haloperidol on formation of 3-methoxytyramine and normetanephrine in mouse brain. Acta Pharmacol. Toxicol. 20, 140–144 (1963)Google Scholar
  7. Collins, G. G. S.: Effect of aminooxyacetic acid, thiosemicarbazide and haloperidol on the metabolism and half-lives of glutamate and GABA in rat brain. Biochem. Pharmacol. 22, 101–111 (1973)Google Scholar
  8. Costall, B., Naylor, R. J.: Mesolimbic involvement with behavioural effects indicating antipsychotic activity. Eur. J. Pharmacol. 27, 46–58 (1974)Google Scholar
  9. Fisher, R., Norris, J. W., Gilka, L.: GABA in Huntington's chorea. Lancet I, 506, (1974)Google Scholar
  10. Haefely, W., Kulcsár, A., Möhler, H., Pieri, L., Polc, P., Schaffner, R.: Possible involvement of GABA in the central actions of benzodiazepines. In: Mechanism of action of benzodiazepines, E. Costa and P. Greengard, eds., pp. 131–151. New York: Raven Press 1975Google Scholar
  11. Hawkins, J. E., Sarett, L. H.: On the efficacy of aspargine, glutamine, γ-aminobutyric acid and 2-pyrrolidinone in preventing chemically induced seizures in mice. Clin. Chim. Acta 2, 48 (1957)Google Scholar
  12. Keller, H. H., Schaffner, R., Haefely, W.: Interactions of benzodiazepines with neuroleptics at central dopamine neurones. Naunyn Schmiedebergs. Arch. Pharmacol. 294, 1–7 (1976)Google Scholar
  13. Kuriyama, K., Sze, P. Y.: Blood brain barrier to H3-γ-aminobutyric acid in normal and aminooxyacetic acid treated animals. Neuropharmacology 10, 103–108 (1971)Google Scholar
  14. Morroni, O. B.: Immediate clinical results with gammaaminobutyric acid B6 in schizophrenias and deliriums. Sem. Med. (B Air) 123, 892–900 (1963)Google Scholar
  15. Randrup, A., Munkvad, I.: Behavioural stereotypies induced by pharmacological agents. Pharmacopsychiatr. Neuropsychopharmakol. 1, 18–26 (1968)Google Scholar
  16. Roberts, E.: A model of the vertibrate nervous system based on distribution: a key role of the GABA system. In: Neurohumoral coding of brain function, R. D. Myers, ed., pp. 419–449. New York: Plenum 1974Google Scholar
  17. Saad, S. F.: Pharmacological actions of gamma-aminobutyric acid, a review article. Mater Med. Pol. 10, 46–53 (1978)Google Scholar
  18. Tower, D. B.: The administration of gammaaminobutyric acid to man: systemic effects and anticonvulsant action. In: Inhibition in the nervous system and gammamminobutyric acid, E. Roberts, C. F. Baxter, A. V. Harreveld, C. A. G. Wiersman, W. R. Adey, and K. F. Killam, eds., pp. 562–577. New York: Fergamon 1960Google Scholar
  19. Worms, P., Willigens, M. T., Lloyd, K. G.: GABA involvement in neuroleptic-induced catalepsy. J. Pharm. Pharmacol. 30, 716–718 (1978Google Scholar

Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • J. J. Balsara
    • 1
  • J. H. Jadhav
    • 1
  • A. G. Chandorkar
    • 1
  1. 1.Department of PharmacologyV. M. Medical CollegeSolapurIndia

Personalised recommendations