Abstract
The interaction between various doses of apomorphine and haloperidol on intracranial self-stimulation in the dog was studied using a pradigm in which reinforcing brain-stimulation was controlled by a discriminative auditory stimulus. Reinforced leverpressing was decreased by low doses of apomorphine and completely suppressed by stereotypogenic doses. At various doses of apomorphine, low doses of haloperidol either increased response inhibition by enhancing stereotypy, or increased lever pressing by reducing stereotypy while concomitantly increasing the number of nonreinforced responses. Intermediate to relatively high doses of haloperidol antagonized stereotypy and the response inhibition produced by apomorphine. High doses of haloperidol antagonized stereotypy but also suppressed self-stimulation. Thus, haloperidol is not only able to restore performance capability, but also disturbed reinforcing and discriminative stimulus control.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Ahlenius, S., Engel, J.: Antagonism by haloperidol of the L-dopa-induced disruption of a successive discrimination in the rat. J. Neural Trans. 36, 43–49 (1975)
Colpaert, F. C., van Bever, W. F. M., Leysen, J. E. M. F.: Apomorphine: chemistry, pharmacology, biochemistry. Int. Rev. Neurobiol. 19, 225–268 (1976)
Colpaert, F. C., Niemegeers, C. J. E., Janssen, P. A. J.: Haloperidol blocks the discriminative stimulus properties of lateral hypothalamic stimulation. Eur. J. Pharmacol. 42, 93–97 (1977)
Dua-Sharma, S., Sharma, K. N., Jacobs, H. L.: The canine brain in stereotaxic coordinates. Massachusetts: M.I.T. 1970
Hartmann, E.: Schizophrenia: a theory. Psychopharmacology 49, 1–15 (1976)
Janssen, P. A. J., Niemegeers, C. J. E., Schellekens, K. H. L., Lenaerts, F. M.: Is it possible to predict the clinical effects of neuroleptic drugs (major tranquillizers) from animal data? IV. An improved design for measuring the inhibitory effects of neuroleptic drugs on amphetamine- or apomorphine-induced “chewing” and “agitation” in rats. Arzneim. Forsch. 17, 841–854 (1967)
Niemegeers, C. J. E.: The apomorphine antagonism test in dogs. Pharmacology 6, 353–364 (1971)
Pavlova, O., Kosowski, S., Sadowski, B.: Conditioning of self-stimulation in the dog to acoustic and visual stimuli. In: Brainstimulation reward, A. Wauquier and E. T. Rolls, eds., pp. 403–405. Amsterdam: North-Holland 1976
Randrup, A., Munkvad, I.: Behavioural stereotypies induced by pharmacological agents. Pharmakopsychiatr. Neuropsychopharmakol. 1, 18–26 (1968)
Reyntjes, A. I., Niemegeers, C. J. E., Van Nueten, J. M., Laduron, P., Heykants, I., Schellekens, K. H. L., Marsboom, R., Jageneau, A., Broekaert, A., Janssen, P. A. J.: Domperidone, a novel and safe gastrokinetic antinauseant for the treatment of dyspepsia and vomiting. Arzneim. Forsch. 28, 1194–1196 (1978)
Wauquier, A.: Brain self-stimulation in dogs: the influence of haloperidol, pimozide and pipamperone. Sixth International Congress of Pharmacology, Abstract 821 (1975)
Wauquier, A., Niemegeers, C. J. E.: Intracranial self-stimulation in rats as a function of various stimulus parameters. II. The influence of haloperidol, pimozide and pipamperone on medial forebrain bundle stimulation with monopolar electrodes. Psychopharmacologia (Berl.) 27, 191–202 (1972)
Wauquier, A., Niemegeers, C. J. E.: Intracranial self-stimulation in rats as a function of various stimulus parameters. III. Influence of apomorphine on medial forebrain bundle stimulation with monopolar electrodes. Psychopharmacologia (Berl.) 30, 163–172 (1973)
Wauquier, A., Rolls, E. T.: Brain-stimulation reward, pp. 622. Amsterdam: North Holland 1976
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Wauquier, A., Melis, W., Niemegeers, C.J.E. et al. A putative multipartite model of haloperidol interaction in apomorphine-disturbed behavior of the dog. Psychopharmacology 59, 255–258 (1978). https://doi.org/10.1007/BF00426630
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00426630