Psychopharmacology

, Volume 59, Issue 3, pp 225–229 | Cite as

Etonitazene as a reinforcer: Oral intake of etonitazene by rhesus monkeys

  • Marilyn E. Carroll
  • Richard A. Meisch
Original Investigations

Abstract

Drinking of etonitazene HCl was studied in three rhesus monkeys during daily 3-h sessions. As the drug concentration was increased, the number of liquid deliveries decreased, and etonitazene intake (μg/kg body weight) increased. As fixed-ratio (FR) requirements were increased, rate of responding increased, and liquid deliveries slightly decreased. When water was substituted for the drug, there was a large increase in responding for several sessions, followed by a slow decline to low rates. When etonitazene was reintroduced, responding abruptly increased to previous drug levels. These data suggest that etonitazene can serve as a positive reinforcer when taken orally by rhesus monkeys.

Key words

Rhesus monkeys Etonitazene HCl Etonitazene concentration Etonitazene reinforcement Fixed-ratio schedules Etonitazene drinking Oral self-administration 

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Copyright information

© Springer-Verlag 1978

Authors and Affiliations

  • Marilyn E. Carroll
    • 1
  • Richard A. Meisch
    • 1
  1. 1.Psychiatry Research UnitUniversity of MinnesotaMinneapolisUSA

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