Skip to main content
SpringerLink
Log in

Circadian rhythms of ethanol consumption by mice: A simple computer analysis for chronopharmacology

  • Animal Studies
  • Published:
Psychopharmacology Aims and scope Submit manuscript

Abstract

On the assumption that a sinusoidal curve adequately describes the circadian rhythm of food or fluid consumption by mice, the whole daily pattern can be derived from a few observations. Examples are presented to show that the assumption is valid. This simple curve-fitting by computer is also applicable to analysis of blood levels of drugs administered in the food or drinking fluid. The method should be useful for estimating the magnitude of daily fluctuations in pharmacological variables, including drug intake rates and circulating drug levels.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Freund, G.: Alcohol withdrawal syndrome in mice. Arch. Neurol. (Chic.) 21, 315–320 (1969)

    Google Scholar 

  • Freund, G.: Alcohol consumption and its circadian distribution in mice. J. Nutr. 100, 30–36 (1970)

    Google Scholar 

  • Goldstein, D. B., Arnold, V. W.: Drinking patterns as predictors of alcohol withdrawal reactions in DBA/2J mice. J. Pharmacol. exp. Ther. 199, 408–414 (1976)

    Google Scholar 

  • Halberg, F., Tong, Y. L., Johnson, E. A.: Circadian system phase — An aspect of temporal morpology; Procedures and illustrative examples. In: The cellular aspects of biorhythms, H. von Mayersbach, ed, Berlin-Heidelberg-New York: Springer 1967

    Google Scholar 

  • Kakihana, R., Moore, J. A.: Circadian rhythm of corticosterone in mice: The effect of chronic consumption of alcohol. Psychopharmacologia (Berl.) 46, 301–305 (1976)

    Google Scholar 

  • Pittendrigh, C. S.: Circadian oscillations in cells and the circadian organization of multicellular systems. In: Circadian oscillations and organization in nervous systems, C. S. Pittendrigh, ed., pp. 437–458. Cambridge: MIT Press 1975

    Google Scholar 

  • Reinberg, A.: Chronopharmacology. In: Biological aspects of circadian rhythms, J. N. Mills, ed., pp. 121–152 New York: Plenum Press 1973

    Google Scholar 

  • Reinberg, A., Clench, J., Aymard, N., Galliot, M., Bourdon, R., Gervais, P., Abulker, C., DuPont, J.: Variations circadiennes des effets de l'éthanol et de l'éthanolemie chez l'homme adulte sain. Étude chronopharmocologique. J. Physiol (Paris) 70, 435–456 (1975)

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pharmacology, Stanford University School of Medicine, 94305, Stanford, CA, USA

    Dora B. Goldstein

  2. Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 94305, Stanford, CA, USA

    Ryoko Kakihana

Authors
  1. Dora B. Goldstein
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ryoko Kakihana
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Goldstein, D.B., Kakihana, R. Circadian rhythms of ethanol consumption by mice: A simple computer analysis for chronopharmacology. Psychopharmacology 52, 41–45 (1977). https://doi.org/10.1007/BF00426598

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00426598

Key words

Search

Navigation