, Volume 52, Issue 1, pp 17–23 | Cite as

Effects of oxazolam, cloxazolam, and CS-386, new anti-anxiety drugs, on socially induced suppression and aggression in Pairs of monkeys

  • Toshiharu Kamioka
  • Isao Nakayama
  • Seigo Akiyama
  • Hiromu Takagi
Animal Studies


This experiment was conducted to examine effects of oxazolam, cloxazolam, CS-386, and reference drugs on socially induced suppression and aggression in pairs of monkeys. Oxazolam, cloxazolam, and CS-386, as well as other benzodiazepines, at both ataxic and non-ataxic doses, attenuated the socially induced suppression, but failed to show inhibitory effect on the socially induced aggression. Chlorpromazine, at both slight-sedative and non-sedative doses, reduced neither socially induced suppression nor aggression. Imipramine did not produce any significant effect in this study

Key words

Oxazolam Cloxazolam CS-386 Diazepam Imipramine Chlorpromazine Socially induced suppression Socially induced aggression Monkeys 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Ando, K., Yanagita, T.: Behavioral effects of benzodiazepines on rats. Folia pharmacol. jap. 70, 637–643 (1974)Google Scholar
  2. Blum, K.: Effects of chlordiazepoxide and pentobarbital on conflict behavior in rats. Psychopharmacologia (Berl.) 17, 391–398 (1970)Google Scholar
  3. Bremer, F. J., Cook, H. W., Hahn, W. C.: The effect of chlordiazepoxide on the behavior of rats in a conflict situation. Psychopharmacologia (Berl.) 17, 257–282 (1970)Google Scholar
  4. Estes, W. K., Skinner, B. F.: Some quantitave properties of anxiety. J. exp. Psychol. 29, 390–400 (1941)Google Scholar
  5. Geller, I.: Relative potencies of benzodiazepines as measured by their effect on conflict behavior. Arch. int. Pharmacodyn. 149, 243–247 (1964)Google Scholar
  6. Geller, I., John, T., Kulah, J., Joseph, S.: The effects of chlordiazepoxide and chlorpromazine on a punished discrimination. Psychopharmacologia (Berl.) 3, 374–385 (1962)Google Scholar
  7. Geller, I., Seifter, J.: The effects of meprobamate, barbiturates, d-amphetamine and promazine on experimentally induced conflict in the rats. Psychopharmacologia (Berl.) 1, 482–492 (1960)Google Scholar
  8. Gluckman, M. I.: Pharmacology of oxazepam, a new antianxiety agent. Curr. ther. Res. 7, 721–740 (1965)Google Scholar
  9. Gluckman, M. I.: Pharmacology of 7-chloro-5-(10-chlorphenyl)-1,3-dihydro-3-hydro-2H-1,4-benzodiazepin-2-one. Arzneimittel-Forsch. 21, 1049 (1971)Google Scholar
  10. Kamioka, T., Takagi, H., Kobayashi, S., Suzuki, Y.: Pharmacological studies on 10-chloro-11b-(2-chlorophenyl)-2,3,5,6,7,11b-hexahydrobenzo-[6,7]-1,4-diazepino[5,4-b]-oxazol-6-one (CS-370). A new psychosedative agent. Arzneimittel-Forsch. 22, 884–891 (1972)Google Scholar
  11. Klupp, H., Kahling, J.: Pharmakologische Wirkungen von 7-chlor-1,3-dihydro-3-hydroxy-5-phenyl-2H-1,4-diazepine-2-on. Arzneimittel-Forsch. 15, 359–364 (1965)Google Scholar
  12. Kobayashi, S., Kamicka, T., Nishio, S., Nakayama, I., Takagi, H.: Pharmacology of benzodiazepinoxazole derivative (In Japanese), Abst. of 91st annual meeting of the pharmaceutical society of Japan, pp. 451, Fukuoka, Japan (1971)Google Scholar
  13. Mascio, D. A.: The effects of benzodiazepines on aggression: reduced or increased? Psychopharmacologia (Berl.) 30, 95 (1973)Google Scholar
  14. Morrison, C. F., Stephenson, J. A.: Drug effect on a measure of unconditioned avoidance in the rats. Psychopharmacologia (Berl.) 18, 133–143 (1970)Google Scholar
  15. Norton, S.: Example of behavioral score sheets. In: Evaluation of drug activity: Pharmacometrics. D. R. Laurence and A. L. Bacharach, eds., p. 226. London-New York: 1964. — The score sheets were reprinted from Psychotropic Drugs, Garattini and Ghetti, eds., p. 73. Amsterdam: ElsevierGoogle Scholar
  16. Randall, L. O., Heise, G. A., Shalleck, W., Bagdon, R. E., Banziger, R. F., Brois, A., Moe, R. A., Abrams, W. B.: Pharmacological and clinical studies on valium, a new psychotherapeutic agent of the benzodiazepine class. Curr. ther. Res. 3, 405–424 (1961)Google Scholar
  17. Randall, L. O., Shalleck, C. L., Banziger, R. F.: Pharmacology of metabolites of chlordiazepoxide and diazepam. Curr. ther. Res. 7, 590–606 (1965)Google Scholar
  18. Randall, L. O., Shalleck, W., Banziger, R. F., Moe, R. A.: Zur Pharmacologic des neuen Psychopharmacoms 7-chloro-2,3-dihydro-1-methyl-5-phenyl-1H-1,4-benzodiazepine. Arzneimittel-Forsch. 18, 1542–1545 (1968)Google Scholar
  19. Randall, L. O., Shalleck, W., Schackel, C. L., Stefko, P. L., Banziger, R. F., Pool, W., Moe, R. A.: Pharmacological studies on flurazepam hydrochloride, a new psychotropic agent of the benzodiazepine class. 178, 216 (1969)Google Scholar
  20. Robichaud, R. C., Glys, J. A., Sledge, K. L., Hillyard, I. W.: The pharmacology of prazepam, a new benzodiazepine derivative. Arch. int. Pharmacodyn. 185, 213–227 (1970)Google Scholar
  21. Tadokoro, S.: Studies on socially induced behavioral suppression in monkeys. Eastern Psychological Association, 38th Annual Meeting, Boston 1965Google Scholar
  22. Tadokoro, S.: Effects of psychotropic drugs on socially induced suppression and aggression in rhesus monkeys (in Japanese). Nihon Ishikai Zasshi (J. Jap. med. Ass.) 58, 21–27 (1967)Google Scholar
  23. Tadokoro, S., Tadokoro, N.: Disparities of diazepam effect depending on its preparation and administration routes investigated behavioral pharmacologically in rats (in Japanese). Jap. J. clin. Pharmacol. 2, 5–13 (1971)Google Scholar
  24. Tadokoro, S.: Pharmacological tests by animal behaviors (in Japanese). Basic Pharmacol. Ther. 2, 16–33 (1974)Google Scholar
  25. Takagi, H., Kamioka, T., Kobayashi, S., Suzuki, Y., Tachikawa, R.: Pharmacological studies of oxazolasepam, a new psychotropic agents (in Japanese). Folia pharmacol. jap. 66, 107–133 (1970)Google Scholar
  26. Villarreal, J., Tadokoro, S.: In: Research on psychoactive drugs and drug dependence. Research News (Office of Research Administration, The University of Michigan, Ann Arbor) 18, 1–11 (1968)Google Scholar
  27. Vogel, J. R., Bernard, B., Clody, D. E.: A simple and reliable conflict procedure for testing anti-anxiety agents. Psychopharmacologia (Berl.) 21, 1–7 (1971)Google Scholar

Copyright information

© Springer-Verlag 1977

Authors and Affiliations

  • Toshiharu Kamioka
    • 1
  • Isao Nakayama
    • 1
  • Seigo Akiyama
    • 1
  • Hiromu Takagi
    • 1
  1. 1.Central Research LaboratoriesSankyo Co., Ltd.TokyoJapan

Personalised recommendations