Archives of Dermatological Research

, Volume 281, Issue 2, pp 95–98 | Cite as

Cutaneous responses to topical methyl nicotinate in black, oriental, and caucasian subjects

  • C. J. Gean
  • E. Tur
  • H. I. Maibach
  • R. H. Guy
Original Contributions


The response of human skin to topical methyl nicotinate (MN) has been monitored in black, oriental, and caucasian subjects. The study aimed to address the question: “Do racial differences in percutaneous absorption and microcirculatory sensitivity exist?” MN-induced vasodilation was assessed visually and by laser Doppler velocimetry (LDV). At three dose levels, in the three subject populations, four parameters were compared: (a) the diameter of the maximum visually perceptible erythematous area (Emx); (b) the area under the erythematous diameter versus time curve (AUE); (c) the maximum LDV response (Lmx); and (d) the area under the LDV response versus time curve (AUL). At p<0.05, AUL (black)>AUL (caucasian) for all MN concentrations; AUL (oriental)>AUL (caucasian) for the higher dose levels. Emx, AUE and Lmx showed no significant differences between races within concentrations. For all subjects, Emx AUE, and AUL were significantly dependent on MN dose whereas Lmx was not. The results suggest that some racial differences in response to topical MN exist and that perception of these distinctions may depend upon the method of measurement.

Key words

Methyl nicotinate Percutaneous absorption rates Microcirculatory sensitivity 


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Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • C. J. Gean
    • 1
    • 2
    • 3
  • E. Tur
    • 1
    • 2
    • 3
  • H. I. Maibach
    • 1
    • 2
    • 3
  • R. H. Guy
    • 1
    • 2
    • 3
  1. 1.Department of Pharmacy, Schoos of Pharmacy and MdicineUniversity of California, San FranciscoSan FranciscoUSA
  2. 2.Department of Pharmaceutical Chemistry, Schoos of Pharmacy and MdicineUniversity of California, San FranciscoSan FranciscoUSA
  3. 3.Department of Dermatology, Schoos of Pharmacy and MdicineUniversity of California, San FranciscoSan FranciscoUSA

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