Psychopharmacology

, Volume 54, Issue 1, pp 21–24 | Cite as

Effects on retention of posttraining amphetamine injections in mice: Interaction with pretraining experience

  • John W. Haycock
  • Roderick van Buskirk
  • Paul E. Gold
Original Investigations

Abstract

These experiments examined the effects of d-amphetamine on retention of one-trial inhibitory (passive) avoidance training in mice. Water-deprived mice were pretrained to lick from a water spout at the end of a darkened compartment. Footschock was administered during licking after 4, 6, or 7 days of pretraining. Retention performance (latency to lick) was measured 24 h after training. The effects on memory of posttraining amphetamine varied not only with amphetamine dose but also with the amount of pretraining. In animals pretraining for 7 days, 0.3 and 1.0 mg/kg but not 0.03, 0.1, or 3.0 mg/kg posttraining amphetamine significantly enhanced later retention performance. In mice pretrained for 6 days, 1 mg/kg amphetamine also enhanced retention performance. However, in mice pretrained for only 4 days, 1 mg/kg amphetamine impaired later retention performance. These results are consistent with the view that posttraining treatments may affect memory storage processes by interacting with training-related arousal levels.

Key words

Amphetamine Memory storage processes Avoidance training Retrograde memory enhancement Retrograde amnesia 

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Copyright information

© Springer-Verlag 1977

Authors and Affiliations

  • John W. Haycock
    • 1
  • Roderick van Buskirk
    • 1
  • Paul E. Gold
    • 1
  1. 1.Department of Psychobiology, School of Biological SciencesUniversity of CaliforniaIrvineU.S.A.

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