Abstract
Chlordiazepoxide (5 and 10 mg/kg) and diazepam (2.5 mg/kg) reduced the latency to eat and enhanced feeding response to familiar food in a food-preference test. The increased feeding response resulted from an increased frequency of individual eating episodes (bouts) without significant change in the episode duration. Experiment II indicated that this facilitatory action of the two drugs was not dependent on the presence of principal novelty cues in the food-preference test. Diazepam (5 mg/kg), in contrast, enhanced the feeding responses to novel food in the food preference test. Experiment III demonstrated that although diazepam can counteract induced food neophobia, its facilitory action on the response to novel foods may be mediated by a mechanism which can operate independently of food neophobia.
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References
Aitken, P. P., Sheldon, M.: Electric shock rats' preference for the familiar arm of a maze. Br. J. Psychol. 61, 95–97 (1970)
Box, B. M., Mogenson, G. J.: Alterations in ingestive behaviors after bilateral lesions of the amygdala in the rat. Physiol. Behav. 15, 679–688 (1975)
Burton, M. J., Cooper, S. J., Posadas-Andrews, A.: Interactions between chlordiazepoxide and food deprivation determining choice in a food-preference test. Br. J. Pharmacol. 68, 157–158 (1980)
Cooper, S. J.: Benzodiazepines as appetite-enhancing compounds. Appetite 1, 7–19 (1980)
Cooper, S. J., Crummy, Y. M. T.: Enhanced choice of familiar food in a food preference test after chlordiazepoxide administration. Psychopharmacology 59, 51–56 (1978)
Cooper, S. J., Francis, R. L.: Effects of acute or chronic administration of chlordiazepoxide on feeding parameters using two food textures in the rat. J. Pharm. Pharmacol. 31, 743–746 (1979)
Cooper, S. J., McClelland, A.: Effects of chlordiazepoxide, food familiarization, and prior shock experience on food choice in rats. Pharmacol. Biochem. Behav. 12, 23–28 (1980)
Cooper, S. J., Sweeney, K. F., Toates, F. M.: Effects of spiperone on feeding performance in a food preference test. Psychopharmacology 63, 301–305 (1979)
Corey, D. T.: An investigation of the neotic deficits produced by basolateral amygdala lesions in the rat. Doctoral dissertation, York University, Canada 1978a
Corey, D. T.: The determinants of exploration and neophobia. Neurosci. Biobehav. Rev. 2, 235–253 (1978b)
Fletcher, A., Green, S. E., Hodges, H. M.: Evidence for a role of GABA in benzodiazepine effects on feeding in rats. Br. J. Pharmacol., in press (1980)
Haywood, H. C., Wachs, T. D.: Effects of arousing stimulation upon novelty preference in rats. Br. J. Psychol. 58, 77–84 (1967)
Johnson, D. N.: Effect of diazepam on food consumption in rats. Psychopharmacology 56, 111–112 (1978)
Nachman, M., Ashe, J. H.: Effects of basolateral amygdala lesions on neophobia, learned taste aversions and sodium appetite in rats. J. Comp. Physiol. Psychol. 87, 622–643 (1974)
Poschel, B. P. H.: A simple and specific screen for benzodiazepinelike drugs. Psychopharmacologia 19, 193–198 (1971)
Rolls, E. T., Rolls, B. J.: Altered food preferences after lesions in the basolateral region of the amygdala in the rat. J. Comp. Physiol. Psychol. 83, 248–259 (1973)
Winer, B. J.: Statistical principles in experimental design. New York: McGraw Hill 1971
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Cooper, S.J. Effects of chlordiazepoxide and diazepam on feeding performance in a food-preference test. Psychopharmacology 69, 73–78 (1980). https://doi.org/10.1007/BF00426525
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DOI: https://doi.org/10.1007/BF00426525