Abstract
The effect of orotic acid and central stimulants on retention of shuttle-box avoidance was investigated in rats. Orotic acid (100 mg/kg) was injected 30 min before training; caffeine (20 mg/kg), strychnine (1 mg/kg), or methylphenidate (10 mg/kg) were injected immediately after training. When given alone, these drugs improved avoidance retention when tested 24h after training. However, improvement of retention was much more evident when orotic acid was given in combination with a stimulant. The data are discussed in relation to the role of macromolecule synthesis and arousal in memory formation.
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Yonkov, D., Wetzel, W., Matthies, H. et al. Improvement of shuttle-box avoidance by combinations of orotic acid and central stimulants. Psychopharmacology 73, 399–401 (1981). https://doi.org/10.1007/BF00426475
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DOI: https://doi.org/10.1007/BF00426475