Molecular and Cellular Biochemistry

, Volume 156, Issue 2, pp 173–178 | Cite as

Muscle ubiquinone in male effort angina patients

  • Jan Karlsson
  • Lijun Lin
  • Sigurd Gunnes
  • Christer Sylvén
  • Hans Åström


Seven (7) males with effort angina and listed for coronary by-pass surgery had muscle biopsies taken from their vastus lateralis muscle for determination of muscle fiber types (%ST), ubiquinone (vitamin Q, UQ), oxidative and fermentative enzyme activities. Graded cycle ergometer exercise to determine intensities corresponding to onset of blood lactate accumulation set to 2.0 nimol × 1−1 (WOSLA) and symptom limited exercise (‘maximal’, WSL) were also undertaken. WOBLA was positively related to %ST (r = 0.92, p < 0.001). %ST was on the other hand inversely related to UQ (r =−0.82, p < 0.05), the heart specific LD subunit LD-H (r =−0.96, p < 0.001), the isozyme LD3 as the fraction of LD (%LD3) (r=−0.93, p < 0.01), and the CK isozyme CKMB as the fraction of CK (%CKMB) (r = −0.88, p < 0.05). It was suggested that muscle UQ depletion in the patients was related to molecular oxygen and free oxygen radical formation. The lack of antioxidants then caused a radical trauma specifically to the ST fiber and their mitochondria. This could be a cause and-effect explanation for the selective ST fiber downregulation in effort angina and heart failure in general.

Key words

effort angina antioxidant vitamins ubiquinone vitamin Q muscle fiber types muscle oxidative capacity oxygen availability exercise capacity muscle fiber trauma 


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Copyright information

© Kluwer Academic Publishers 1996

Authors and Affiliations

  • Jan Karlsson
    • 5
  • Lijun Lin
    • 1
  • Sigurd Gunnes
    • 2
  • Christer Sylvén
    • 3
  • Hans Åström
    • 4
  1. 1.Department of Clinical PhysiologyKarolinska InstituteSweden
  2. 2.Department of Thoracic Surgery Karolinska InstituteSweden
  3. 3.Department of Cardiology, Huddinge University HospitalKarolinska InstituteSweden
  4. 4.Department of Thoracic Clinical PhysiologyKarolinska InstituteSweden
  5. 5.OBLA ABVaxholmSweden

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