, Volume 51, Issue 1, pp 81–84 | Cite as

The inhibitory effect of intraventricular administration of serotonin on spontaneous motor activity of rats

  • R. A. Green
  • J. C. Gillin
  • R. J. Wyatt
Animal Studies


Spontaneous motor activity was studied following injection of 1, 10 and 50 μg of serotonin (5-HT) into the lateral ventricle of chronically cannulated rats. During the first 15 min, the rats receiving the higher doses of 5-HT showed significant decrements (P<0.01) in motor activity compared to saline controls. No activation was observed in either group. After 20 min, no significant differences for any treatment condition compared to saline controls were observed. It is concluded that a principal effect of directly increasing brain 5-HT concentration is to decrease activity. Possible mechanisms for this effect are discussed.

Key words

Carbidopa Serotonin Activity Intraventricular 


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Copyright information

© Springer-Verlag 1976

Authors and Affiliations

  • R. A. Green
    • 1
  • J. C. Gillin
    • 1
  • R. J. Wyatt
    • 1
  1. 1.Laboratory of Clinical Psychopharmacology, Division of Special Mental Health Research, National Institute of Mental HealthSaint Elizabeth's HospitalWashington, D.C.U.S.A.

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