Abstract
This study, comparing polygraphic data and biochemical dosages with a short term rabbit EEG recording technique, shows that Ro 4602 does not have the same quantitative (or even qualitative) effect whether combined with l-Dopa or l-5-HTP. Thus minimal and optimal doses of this inhibitor of the decarboxylase are not the same for the two precursors. Using equimolar doses, clinical effects on the whole appeared to be much more evident with the association Ro 4602-l-5-HTP than with Ro 4602-l-Dopa.
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Aubert, C., Geissbühler, F.: Perfusions de l-5-HTP, associées à un inhibiteur de la décarboxylase, chez le lapin. Données polygraphiques et biochimiques. Psychopharmacologia (Berl.) 45, 97–101 (1975)
Bartholini, G., Constantinidis, J., Tissot, R., Pletscher, A.: Formation of monoamines from various amino acids in the brain after inhibition of extracerebral decarboxylase. Biochem. Pharmacol. 20, 1243–1247 (1971)
Burkard, W. P., Gey, K. F., Pletscher, A.: Inhibition of decarboxylase of aromatic amino acids by 2, 3, 4-trihydroxybenzylhydrazine and its seryl derivative. Arch. Biochem. Biophys. 107, 187–196 (1964)
Christenson, J. G., Dairman, W., Udenfriend, S.: On the identity of dopa decarboxylase and 5-hydroxytryptophandecarboxylase. Proc. nat. Acad. Sci. (Wash.) 69, 343–374 (1972)
Eisenring, J. J.: (En préparation)
Gaillard, J. M., SchÄppi, R., Tissot, R.: Potentialisation des effets centraux de la Dopa après inhibition sélective de la décarboxylase extracérébrale. Arch. int. Pharmacodyn. 180, 423–437 (1969)
Geissbühler, F.: (En préparation)
Monnier, M., Gangloff, H.: Atlas for stereotaxic brain research on the conscious rabbit. Amsterdam: Elsevier 1962
Monnier, M., Tissot, R.: Action de la réserpine et de ses médiateurs (5-hydroxytryptophan-sérotonine et Dopanoradrénaline) sur le comportement et le cerveau du lapin. Helv. physiol. pharmacol. Acta 16, 225–267 (1958)
Pletscher, A.: Hydrazine derivatives and oxygen isosters. In: Handbuch der experimentellen Pharmacologie, Vol. 19, V. Erspamer, ed., pp. 661–666. Berlin-Heidelberg-New York: Springer 1966
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Aubert, C., Geissbühler, F. Propriétés différentielles d'un inhibiteur de la décarboxylase envers la l-Dopa et le l-5-HTP. Données polygraphiques et biochimiques. Psychopharmacologia 45, 93–96 (1975). https://doi.org/10.1007/BF00426216
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DOI: https://doi.org/10.1007/BF00426216