Skip to main content
SpringerLink
Log in

The ineffectiveness of desipramine pretreatment on behavioral effects of 6-hydroxydopamine in nialamide-pretreated rats

  • Published:
Psychopharmacologia Aims and scope Submit manuscript

Abstract

Non-anesthetized rats, pretreated with nialamide (140 mg/kg, 16–18 h earlier) were injected with 6-hydroxydopamine (HBr, 2×250 Μg) into both lateral brain ventricles. Some rats received desipramine (25 mg/kg) 1 h before 6-hydroxydopamine. 6-Hydroxydopamine increased the locomotor activity and produced behavioral stimulation lasting for several hours. On the following days the open-field performance of the rats receiving 6-hydroxydopamine was markedly depressed. Approx. one half of the rats receiving 6-hydroxydopamine died between day 3 and day 10 after the injection. Desipramine pretreatment did not affect the behavioral changes or mortality produced by 6-hydroxydopamine, although it counteracted the depletion of brain noradrenaline brought about by 6-hydroxydopamine. It is concluded that the behavioral changes observed after 6-hydroxydopamine injection in nialamide-pretreated rats are related to the action of 6-hydroxydopamine on dopamine, and not on noradrenaline neurons.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Bell, L. J., Iversen, L. L., Uretsky, N. J.: Time course of the effects of 6-hydroxydopamine on catecholamine-containing neurones in the rat hypothalamus and striatum. Brit. J. Pharmacol. 40, 790–799 (1970)

    Google Scholar 

  • Bloom, F. E., Algeri, S., Gropetti, A., Revuelta, A., Costa, E.: Lesions of central norepinephrine terminals with 6-hydroxydopamine: biochemistry and fine structure. Science 166, 1284–1286 (1969)

    Google Scholar 

  • Breese, G. R., Howard, J. D.: Effect of central catecholamine alterations on the hypothermic response to 6-hydroxydopamine in desipramine treated rats. Brit. J. Pharmacol 43, 671–674 (1971)

    Google Scholar 

  • Breese, G. R., Traylor, T. D.: Effect of 6-hydroxydopamine on brain norepinephrine and dopamine: evidence for selective degeneration of catecholamine neurons. J. Pharmacol. exp. Ther. 174, 413–420 (1970)

    Google Scholar 

  • Breese, G. R., Traylor, T. D.: Depletion of brain noradrenaline and dopamine by 6-hydroxydopamine. Brit. J. Pharmacol. 42, 88–99 (1971)

    Google Scholar 

  • Burkard, W. P., Jalfre, M., Blum, J.: Effect of 6-hydroxydopamine on behaviour and cerebral amine content in rats. Experientia (Basel) 25, 1295–1296 (1969)

    Google Scholar 

  • Carlsson, A., Fuxe, K., Hamberger, B., Lindqvist, M.: Biochemical and histochemical studies on the effects of imipramine-like drugs and (+)-amphetamine on central and peripheral catecholamine neurones. Acta physiol. scand. 67, 481–497 (1966)

    Google Scholar 

  • Champlain, J. de: Degeneration and regrowth of adrenergic nerve fibers in the rat peripheral tissues after 6-hydroxydopamine. Canad. J. Physiol. Pharmacol. 49, 345–355 (1971)

    Google Scholar 

  • Champlain, J. de., Nadeau, R.: 6-Hydroxydopamine, 6-hydroxydopa and degeneration of adrenergic nerves. Fed. Proc. 30, 877–885 (1971)

    Google Scholar 

  • Delbarre, B., Dumas, G., Goionniere, M.: An automated open field method. Psyohopharmacologia (Berl.) 18, 227–230 (1970)

    Google Scholar 

  • Evetts, K. D., Fitzsimons, J. T., Setler, P. E.: Eating caused by 6-hydroxydopamine-induced release of noradrenaline in the diencephalon of the rat. J. Physiol. (Lond.) 223, 35–47 (1972)

    Google Scholar 

  • Evetts, K. D., Iversen, L. L.: Effects of protriptyline on the depletion of catecholamines induced by 6-hydroxydopamine in the rat brain. J. Pharm. Pharmacol. 22, 540–543 (1970)

    Google Scholar 

  • Evetts, K. D., Uretsky, N. J., Iversen, L. L., Iversen, S. D.: Effects of 6-hydroxydopamine on CNS catecholamines, spontaneous motor activity and amphetamine induced hyperactivity in rats. Nature (Lond.) 225, 961–962 (1970)

    Google Scholar 

  • Herman, Z. S., Kmieciak-Kotada, K., Brus, R.: The influence of 6-hydroxydopamine injected to the lateral ventricle of brain in the behaviour of rats and the level of catecholamines and 5-hydroxytryptamine in the brain. Diss. Pharm. Pharmacol. 23, 600–601 (1971)

    Google Scholar 

  • Horn, A. S., Coyle, J. T., Snyder, S. H.: Catecholamine uptake by synaptosomes from rat brain; structure-activity relationships of drugs with differential effects on dopamine and norepinephrine neurons. Molec. Pharmacol. 7, 66–80 (1971)

    Google Scholar 

  • Jalfre, M., Haefely, W.: Effects of some centrally acting agents in rats after intraventricular injections of 6-hxdroxydopamine. In: 6-Hydroxydopamine and catecholamine neurons. T. Malmfors and H. Thoenen, Eds., pp. 333–346. Amsterdam: North Holland 1971

    Google Scholar 

  • Jonsson, Gr., Sachs, Ch.: Effects of 6-hydroxydopamine on the uptake and storage of noradrenaline in sympathetic adrenergic neurons. Europ. J. Pharmacol. 9, 141–155 (1970)

    Google Scholar 

  • Kuchii, M., Shibata, S.: In vitro effect of 6-hydroxydopamine on isolated rat atria. Brit J. Pharmacol. 44, 583–585 (1972)

    Google Scholar 

  • Laverty, R., Taylor, K. M.: Effects of intraventricular 2,4,5-trihydroxyphenylethylamine (6-hydroxydopamine) on rat behaviour and catecholamine metabolism. Brit. J. Pharmacol. 40, 836–846 (1970)

    Google Scholar 

  • Maickel, R. P., Cox, R. H., Jr., Saillant, J., Miller, F. P.: A method for the determination of serotonin and norepnephrine in discrete areas of rat brain. Int. J. Neuropharmacol. 7, 275–281 (1968)

    Google Scholar 

  • Schoenfeld, R. J., Zigmond, M. J.: Effect of 6-hydroxydopamine (HDA) on fixed ratio (FR) performance. Pharmacologist 12, 157 (1970)

    Google Scholar 

  • Schubert, P., Kreutzberg, G. W., Reinhold, K., Herz, A.: Selective uptake of 3H-6-hydroxydopamine by neurons of the central nervous system. Exp. Brain Res. 17, 539–548 (1973)

    Google Scholar 

  • Scotti de Carolis, A., Ziegler, H., Del Basso, P., Longo, V. G.: Central effects of 6-hydroxydopamine. Physiol. Behav. 7, 705–708 (1971)

    Google Scholar 

  • Taylor, K. M., Laverty, R.: The effects of drugs on the behavioural and biochemical actions of intraventricular 6-hydroxydopamine. Europ. J. Pharmacol. 17, 16–24 (19X)

    Google Scholar 

  • Taylor, K. M., Snyder, S. H., Laverty, R.: Dissociation of the behavioral and biochemical actions of 6-hydroxydopamine. Pharmacologist 12, 157 (1970)

    Google Scholar 

  • Thoenen, H.: Biochemical alterations induced by 6-hydroxydopamine in peripheral adrenergic neurons. In: 6-Hydroxydopamine and catecholamine neurons. T. Malforms and H. Thoenen, Eds., pp. 75–85. Amsterdam: North Holland 1971

    Google Scholar 

  • Ungerstedt, U.: 6-Hydroxydopamine induces degeneration of central monoamine neurons. Europ. J. Pharmacol. 5, 107–110 (1968)

    Google Scholar 

  • Ungerstedt, U.: Adipsia and aphagia after 6-hydroxydopamine-induced degeneration of the nigro-striatal dopamine system. Acta physiol. scand. Suppl. 367, 95–122 (1971)

    Google Scholar 

  • Uretsky, N. J., Iversen, L. L.: Effects of 6-hydroxydopamine on noradrenaline-containing neurones in the rat brain. Nature (Lond.) 221, 557–559 (1969)

    Google Scholar 

  • Uretsky, N. J., Iversen, L. L.: Effects of 6-hydroxydopamine on catecholamine-containing neurons in the rat brain. J. Neurochem. 17, 269–278 (1970)

    Google Scholar 

  • Vetulani, J., Reichenberg, K., Wiszniowska, G.: Asymmetric behavioral and biochemical effects of unilateral injections of 6-hydroxydopamine into the lateral brain ventricle of the rat. Europ. J. Pharmacol. 19, 231–238 (1972)

    Google Scholar 

Download references

Author information

Author notes

  1. Jerzy Vetulani

    Present address: Vanderbilt University School of Medicine, Department of Pharmacology, T.N.I., 37217, Nashville, Tennessee

Authors and Affiliations

  1. Department of Pharmacology, Polish Academy of Sciences, 31-344, Krakow, Poland

    Jerzy Vetulani, Krystyna Reichenberg & Grażyna Wiszniowska

Authors
  1. Jerzy Vetulani
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Krystyna Reichenberg
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Grażyna Wiszniowska
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Vetulani, J., Reichenberg, K. & Wiszniowska, G. The ineffectiveness of desipramine pretreatment on behavioral effects of 6-hydroxydopamine in nialamide-pretreated rats. Psychopharmacologia 38, 173–180 (1974). https://doi.org/10.1007/BF00426111

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00426111

Key words

Search

Navigation