Archives of Orthopaedic and Trauma Surgery

, Volume 116, Issue 3, pp 125–128 | Cite as

Allogeneic vascularized grafting of a human knee joint with postoperative immunosuppression

  • G. O. Hofmann
  • M. H. Kirschner
  • F. D. Wagner
  • W. Land
  • V. Bühren
Original Article


In this paper we report the first successful allogeneic vascularized transplantation of a fresh and perfused human knee joint. A 17-year-old male had lost his knee in a motorvehicle accident. The graft was harvested from a multiorgan donor, perfused with 41 UW solution and transplanted within 21 h. Osteosyntheses were performed employing intramedullary nails. Immunosuppression was based mainly on two drugs: cyclosporin A and azathioprine. Five months after the operation the patient is fully mobilized, and the graft perfusion still intact. Osteotomies of the femur and tibia demonstrate callus formation and osseous consolidation.


Public Health Cyclosporin Knee Joint Callus Formation Intramedullary Nail 
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Copyright information

© Springer-Verlag 1997

Authors and Affiliations

  • G. O. Hofmann
    • 1
  • M. H. Kirschner
    • 2
  • F. D. Wagner
    • 1
  • W. Land
    • 1
  • V. Bühren
    • 1
  1. 1.Berufsgenossenschaftliche Unfallklinik MumauMurnauGermany
  2. 2.Abteilung für Transplantationschirurgie der Chirurgischen Klinik und Poliklinik und Institut für Chirurgische Forschung der Ludwig-Maximilians-Universität MünchenGermany

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